Methodologies to investigate intracellular barriers for nucleic acid delivery in non-viral gene therapy
A plethora of biological barriers, intended to defend tissues and cells against external
influences, stand in the way of efficient nucleic acid delivery by non-viral nanoplexes. Even …
influences, stand in the way of efficient nucleic acid delivery by non-viral nanoplexes. Even …
Near infrared fluorescent peptide nanoparticles for enhancing esophageal cancer therapeutic efficacy
Various types of nanoparticles have been proposed for targeted drug delivering, imaging,
and tracking of therapeutic agents. However, highly biocompatible nanoparticles with …
and tracking of therapeutic agents. However, highly biocompatible nanoparticles with …
Titanium dioxide nanoparticles preferentially bind in subdomains IB, IIA of HSA and minor groove of DNA
Titanium dioxide nanoparticles (TiO2-NPs) interaction with human serum albumin (HSA)
and DNA was studied by UV–visible spectroscopy, spectrofluorescence, circular dichroism …
and DNA was studied by UV–visible spectroscopy, spectrofluorescence, circular dichroism …
Endocytic selective toxicity of rhodamine 6G nanoGUMBOS in breast cancer cells
Herein, we report on the role of endocytosis in the selective chemotherpeutic toxicity of
rhodamine 6G (R6G) based nanomaterials, ie, nanoGUMBOS, that are derived from a group …
rhodamine 6G (R6G) based nanomaterials, ie, nanoGUMBOS, that are derived from a group …
Redox proteomic insights into involvement of clathrin-mediated endocytosis in silver nanoparticles toxicity to Mytilus galloprovincialis
Clathrin-mediated endocytosis is a major mode of nanoparticle (NP) internalization into
cells. However, influence of internalization routes on nanoparticle toxicity is poorly …
cells. However, influence of internalization routes on nanoparticle toxicity is poorly …
Linker chemistry dictates the delivery of a phototoxic organometallic rhenium (I) complex to human cervical cancer cells from core crosslinked star polymer …
We have investigated core-crosslinked star polymer nanoparticles designed with tunable
release chemistries as potential nanocarriers for a photoactive Re (I) organometallic …
release chemistries as potential nanocarriers for a photoactive Re (I) organometallic …
[HTML][HTML] New properties of a bioinspired pyridine benzimidazole compound as a novel differential staining agent for endoplasmic reticulum and Golgi apparatus in …
FM Llancalahuen, JA Fuentes, A Carreño… - Frontiers in …, 2018 - frontiersin.org
In this study, we explored new properties of the bioinspired pyridine benzimidazole
compound B2 (2, 4-di-tert-butyl-6-(3H-imidazo [4, 5-c] pyridine-2-yl) phenol) regarding its …
compound B2 (2, 4-di-tert-butyl-6-(3H-imidazo [4, 5-c] pyridine-2-yl) phenol) regarding its …
Investigation of Receptor-Mediated Cyanocobalamin (Vitamin B12) Transport across the Inner Blood–Retinal Barrier Using Fluorescence-Labeled Cyanocobalamin
Y Kinoshita, K Nogami, R Jomura… - Molecular …, 2018 - ACS Publications
The blood-to-retina supply of cyanocobalamin (vitamin B12) across the blood–retinal barrier
(BRB) was investigated by synthesizing a fluorescence-labeled cyanocobalamin (Cy5 …
(BRB) was investigated by synthesizing a fluorescence-labeled cyanocobalamin (Cy5 …
Chemical modification of chitosan as a gene transporter
HL Jiang, L Xing, CQ Luo, TJ Zhou… - Current Organic …, 2018 - ingentaconnect.com
Background: Due to poor safety characterstics, viral vectors in gene delivery are usually
limited in clinical application. Non-viral vectors have focused on the development of effective …
limited in clinical application. Non-viral vectors have focused on the development of effective …
[HTML][HTML] Glycosylated and non-glycosylated quantum dot-displayed peptides trafficked indiscriminately inside lung cancer cells but discriminately sorted in normal lung …
RS Tan - asian journal of pharmaceutical sciences, 2018 - Elsevier
Difference in sub-cellular trafficking of glycosylated and naked peptides, between normal
and lung cancer cells, was established. Normal lung tissue discriminately sorted …
and lung cancer cells, was established. Normal lung tissue discriminately sorted …