Methodologies to investigate intracellular barriers for nucleic acid delivery in non-viral gene therapy

LMP Vermeulen, T Brans, SC De Smedt, K Remaut… - Nano Today, 2018 - Elsevier
A plethora of biological barriers, intended to defend tissues and cells against external
influences, stand in the way of efficient nucleic acid delivery by non-viral nanoplexes. Even …

Near infrared fluorescent peptide nanoparticles for enhancing esophageal cancer therapeutic efficacy

Z Fan, Y Chang, C Cui, L Sun, DH Wang, Z Pan… - Nature …, 2018 - nature.com
Various types of nanoparticles have been proposed for targeted drug delivering, imaging,
and tracking of therapeutic agents. However, highly biocompatible nanoparticles with …

Titanium dioxide nanoparticles preferentially bind in subdomains IB, IIA of HSA and minor groove of DNA

K Ali, F Abul Qais, S Dwivedi… - Journal of …, 2018 - Taylor & Francis
Titanium dioxide nanoparticles (TiO2-NPs) interaction with human serum albumin (HSA)
and DNA was studied by UV–visible spectroscopy, spectrofluorescence, circular dichroism …

Endocytic selective toxicity of rhodamine 6G nanoGUMBOS in breast cancer cells

N Bhattarai, JM Mathis, M Chen, RL Perez… - Molecular …, 2018 - ACS Publications
Herein, we report on the role of endocytosis in the selective chemotherpeutic toxicity of
rhodamine 6G (R6G) based nanomaterials, ie, nanoGUMBOS, that are derived from a group …

Redox proteomic insights into involvement of clathrin-mediated endocytosis in silver nanoparticles toxicity to Mytilus galloprovincialis

Y Bouallegui, R Ben Younes, R Oueslati, D Sheehan - PLoS One, 2018 - journals.plos.org
Clathrin-mediated endocytosis is a major mode of nanoparticle (NP) internalization into
cells. However, influence of internalization routes on nanoparticle toxicity is poorly …

Linker chemistry dictates the delivery of a phototoxic organometallic rhenium (I) complex to human cervical cancer cells from core crosslinked star polymer …

SH Yu, M Patra, S Ferrari, PR Garcia… - Journal of materials …, 2018 - pubs.rsc.org
We have investigated core-crosslinked star polymer nanoparticles designed with tunable
release chemistries as potential nanocarriers for a photoactive Re (I) organometallic …

[HTML][HTML] New properties of a bioinspired pyridine benzimidazole compound as a novel differential staining agent for endoplasmic reticulum and Golgi apparatus in …

FM Llancalahuen, JA Fuentes, A Carreño… - Frontiers in …, 2018 - frontiersin.org
In this study, we explored new properties of the bioinspired pyridine benzimidazole
compound B2 (2, 4-di-tert-butyl-6-(3H-imidazo [4, 5-c] pyridine-2-yl) phenol) regarding its …

Investigation of Receptor-Mediated Cyanocobalamin (Vitamin B12) Transport across the Inner Blood–Retinal Barrier Using Fluorescence-Labeled Cyanocobalamin

Y Kinoshita, K Nogami, R Jomura… - Molecular …, 2018 - ACS Publications
The blood-to-retina supply of cyanocobalamin (vitamin B12) across the blood–retinal barrier
(BRB) was investigated by synthesizing a fluorescence-labeled cyanocobalamin (Cy5 …

Chemical modification of chitosan as a gene transporter

HL Jiang, L Xing, CQ Luo, TJ Zhou… - Current Organic …, 2018 - ingentaconnect.com
Background: Due to poor safety characterstics, viral vectors in gene delivery are usually
limited in clinical application. Non-viral vectors have focused on the development of effective …

[HTML][HTML] Glycosylated and non-glycosylated quantum dot-displayed peptides trafficked indiscriminately inside lung cancer cells but discriminately sorted in normal lung …

RS Tan - asian journal of pharmaceutical sciences, 2018 - Elsevier
Difference in sub-cellular trafficking of glycosylated and naked peptides, between normal
and lung cancer cells, was established. Normal lung tissue discriminately sorted …