The Rise and Rise of Nicotiana benthamiana: A Plant for All Reasons

J Bally, H Jung, C Mortimer, F Naim… - Annual review of …, 2018 - annualreviews.org
A decade ago, the value of Nicotiana benthamiana as a tool for plant molecular biologists
was beginning to be appreciated. Scientists were using it to study plant-microbe and protein …

Pharmacological benefits of neferine-A comprehensive review

SM Asokan, R Mariappan, S Muthusamy… - Life sciences, 2018 - Elsevier
This article recapitulates the existing in vitro and in vivo studies focusing on the effects of
neferine-an alkaloid derivative of lotus plant, in various disease models and its effects on …

Augmenting the Calvin–Benson–Bassham cycle by a synthetic malyl-CoA-glycerate carbon fixation pathway

H Yu, X Li, F Duchoud, DS Chuang, JC Liao - Nature Communications, 2018 - nature.com
Abstract The Calvin–Benson–Bassham (CBB) cycle is presumably evolved for optimal
synthesis of C3 sugars, but not for the production of C2 metabolite acetyl-CoA. The carbon …

Biocatalyzed C− C bond formation for the production of alkaloids

MD Patil, G Grogan, H Yun - ChemCatChem, 2018 - Wiley Online Library
Traditional methods of chemical synthesis of alkaloids exhibit various problems such as lack
of enantioselectivity, the use of toxic chemical and intermediates, and multiple numbers of …

Chemo-enzymatic Total Syntheses of Jorunnamycin A, Saframycin A, and N-Fmoc Saframycin Y3

R Tanifuji, K Koketsu, M Takakura… - Journal of the …, 2018 - ACS Publications
The antitumor tetrahydroisoquinoline (THIQ) alkaloids share a common pentacyclic scaffold
that is biosynthesized by nonribosomal peptide synthetases involving unique enzymatic …

Upstream biomanufacturing of pharmaceutical colchicine

G Sivakumar - Critical reviews in biotechnology, 2018 - Taylor & Francis
The plant-based colchicine potentially affects major diseases such as cardiovascular events,
cancers and gout. Gloriosa superba seeds are a conventional pharmaceutical source of …

Biochemistry of vegetables: secondary metabolites in vegetables—terpenoids, phenolics, alkaloids, and sulfur‐containing compounds

MG Lobo, N Hounsome… - Handbook of vegetables …, 2018 - Wiley Online Library
This chapter provides an overview of the major classes of plant secondary metabolites found
in vegetables, emphasizing their roles in human health and nutrition. These metabolites …

Simultaneous over-expression and silencing of some benzylisoquinoline alkaloid biosynthetic genes in opium poppy

SM Sohrabi, A Ismaili… - Industrial Crops and …, 2018 - Elsevier
Opium poppy (Papaver somniferum L.) remains the only commercial source for several
pharmaceutical alkaloids. In present study, opium poppy plants were genetically …

Microbial Synthesis of Plant Alkaloids

ME Pyne, L Narcross, CIC Hansen, A Campbell… - Biotechnology of Natural …, 2018 - Springer
Of the roughly 12,000 alkaloids naturally produced by plant species, roughly half comprise
the monoterpene indole alkaloid (MIA) and benzylisoquinoline alkaloid (BIA) families. These …

Precursor-directed biosynthesis and semi-synthesis of natural products

E Kalkreuter, SM Carpenter, GJ Williams - 2018 - books.rsc.org
Natural products comprise just approximately 0.7% of the commercially available chemical
space but constitute a significantly larger portion of the biologically active space. 1, 2 As …