Most neurodegenerative disorders are associated with aggregated protein deposits. In the
case of Alzheimer disease (AD), extracellular amyloid-β (Aβ) aggregates and intracellular …

The incidence of dementia is expected to double in the next 20 years and will contribute to
heavy social and economic burden. Dementia is caused by neuronal loss that leads to brain …

The relationships between β-amyloid (Aβ), tau and neurodegeneration within Alzheimer's
Disease pathogenesis are not fully understood. To explore these associations in vivo, we …

Alzheimer's disease (AD) is associated with extensive alterations in grey matter
microstructure, but our ability to quantify this in vivo is limited. Neurite orientation dispersion …

Background: Imaging studies in Alzheimer's disease (AD) have yet to answer the underlying
questions concerning the relationship among tau retention, neuroinflammation, network …

Alzheimer's disease is the most common form of dementia and is a significant burden for
affected patients, carers, and health systems. Great advances have been made in …

Neuropathological and in vivo brain imaging studies agree that the cornu ammonis 1 and
subiculum subfields of the hippocampus are most vulnerable to atrophy in the prodromal …

A single nucleotide polymorphism, rs17070145, in the KIdney and BRAin expressed protein
(KIBRA) gene has been associated with cognition and hippocampal volume in cognitively …

Objective To examine neural correlates of intellectual activity underlying multiple pathways
imparting reserve by testing that higher intellectual activity is associated with lower brain …

Alzheimer's disease (AD) is characterized by an accumulation of β-amyloid (Aβ 42)
accompanied by brain atrophy and cognitive decline. Several recent studies have shown …