Inflammageing and metaflammation: the yin and yang of type 2 diabetes
F Prattichizzo, V De Nigris, R Spiga, E Mancuso… - Ageing research …, 2018 - Elsevier
Type 2 diabetes mellitus (T2DM) is characterised by chronic low-grade inflammation,
recently referred to as 'metaflammation', a relevant factor contributing to the development of …
recently referred to as 'metaflammation', a relevant factor contributing to the development of …
[HTML][HTML] DNA methylation in the pathogenesis of type 2 diabetes in humans
Abstract Background Type 2 diabetes (T2D) is a multifactorial, polygenic disease caused by
impaired insulin secretion and insulin resistance. Genome-wide association studies (GWAS) …
impaired insulin secretion and insulin resistance. Genome-wide association studies (GWAS) …
DNA methylation markers associated with type 2 diabetes, fasting glucose and HbA1c levels: a systematic review and replication in a case–control sample of the …
Aims/hypothesis Epigenetic mechanisms may play an important role in the aetiology of type
2 diabetes. Recent epigenome-wide association studies (EWASs) identified several DNA …
2 diabetes. Recent epigenome-wide association studies (EWASs) identified several DNA …
Epigenetic reprogramming in metabolic disorders: nutritional factors and beyond
Z Cheng, L Zheng, FA Almeida - The Journal of nutritional biochemistry, 2018 - Elsevier
Environmental factors (eg, malnutrition and physical inactivity) contribute largely to
metabolic disorders including obesity, type 2 diabetes, cardiometabolic disease and …
metabolic disorders including obesity, type 2 diabetes, cardiometabolic disease and …
Maternal genome-wide DNA methylation profiling in gestational diabetes shows distinctive disease-associated changes relative to matched healthy pregnancies
Several recent reports have described associations between gestational diabetes (GDM)
and changes to the epigenomic landscape where the DNA samples were derived from …
and changes to the epigenomic landscape where the DNA samples were derived from …
Developing a toolkit for the assessment and monitoring of musculoskeletal ageing
The complexities and heterogeneity of the ageing process have slowed the development of
consensus on appropriate biomarkers of healthy ageing. The Medical Research Council …
consensus on appropriate biomarkers of healthy ageing. The Medical Research Council …
Altered DNA methylation in liver and adipose tissues derived from individuals with obesity and type 2 diabetes
Background Obesity is a well-recognized risk factor for insulin resistance and type 2
diabetes (T2D), although the precise mechanisms underlying the relationship remain …
diabetes (T2D), although the precise mechanisms underlying the relationship remain …
An Epigenetic Signature in Adipose Tissue Is Linked to Nicotinamide N‐Methyltransferase Gene Expression
AB Crujeiras, P Pissios… - Molecular nutrition & …, 2018 - Wiley Online Library
Scope The enzyme nicotinamide N‐methyltransferase (NNMT) is a major methyltransferase
in adipose tissue. We hypothesized an epigenetic signature in association with NNMT gene …
in adipose tissue. We hypothesized an epigenetic signature in association with NNMT gene …
Investigating the epigenetic discrimination of identical twins using buccal swabs, saliva, and cigarette butts in the forensic setting
Monozygotic (MZ) twins are typically indistinguishable via forensic DNA profiling. Recently,
we demonstrated that epigenetic differentiation of MZ twins is feasible; however, proportions …
we demonstrated that epigenetic differentiation of MZ twins is feasible; however, proportions …
Crime investigation through DNA methylation analysis: methods and applications in forensics
AK Rana - Egyptian Journal of Forensic Sciences, 2018 - Springer
Discerning monozygotic twins, precisely predicting the age of human beings and most
importantly interpreting human behavior remains a big challenge in forensic science …
importantly interpreting human behavior remains a big challenge in forensic science …