Biomaterial-assisted targeted modulation of immune cells in cancer treatment

H Wang, DJ Mooney - Nature materials, 2018 - nature.com
The past decade has witnessed the accelerating development of immunotherapies for
cancer treatment. Immune checkpoint blockade therapies and chimeric antigen receptor …

Leveraging engineering of cells for drug delivery

Z Chen, Q Hu, Z Gu - Accounts of chemical research, 2018 - ACS Publications
Conspectus Cell therapy has become a momentum-gathering treatment strategy for a variety
of diseases, including cancer, diabetes, hemophilia, and cardiomyopathy. However, clinical …

Enhancing T cell therapy through TCR-signaling-responsive nanoparticle drug delivery

L Tang, Y Zheng, MB Melo, L Mabardi… - Nature …, 2018 - nature.com
Adoptive cell therapy (ACT) with antigen-specific T cells has shown remarkable clinical
success; however, approaches to safely and effectively augment T cell function, especially in …

Immunoengineering with biomaterials for enhanced cancer immunotherapy

YQ Xie, L Wei, L Tang - Wiley Interdisciplinary Reviews …, 2018 - Wiley Online Library
Cancer immunotherapy has recently shown dramatic clinical success inducing durable
response in patients of a wide variety of malignancies. Further improvement of the clinical …

Cytokine‐functionalized synthetic dendritic cells for T cell targeted immunotherapies

LJ Eggermont, R Hammink, KG Blank… - Advanced …, 2018 - Wiley Online Library
Widespread application of cytokine‐based therapies is hampered by severe toxic side
effects, resulting from off‐target (immune) cell stimulation. This emphasizes the need for …

SPIN: Rapid synthesis, purification, and concentration of small drug-loaded liposomes

SA Roberts, N Parikh, RJ Blower… - Journal of Liposome …, 2018 - Taylor & Francis
Liposomes are one of the most studied nano-delivery systems. However, only a handful of
formulations have received FDA approval. Existing liposome synthesis techniques are …

Emerging Nanotechnologies for Cancer Immunodiagnosis and Cancer Immunotherapies

AM Wen, NF Steinmetz… - Molecular Medicines for …, 2018 - api.taylorfrancis.com
As described all throughout this book, nanoparticles exhibit novel properties, which largely
differ from the bulk materials due to their enhanced surface to volume ratios. These include …

[图书][B] Bioinspired Drug Delivery System for Anticancer Therapy

Q Hu - 2018 - search.proquest.com
The development of bioinspired drug delivery system by virtue of biology, such as mimicking
structural and functional aspects of natural bioparticulates or leveraging physiological …

[引用][C] Nanocapsule-based vaccination for inhibition of tumor escape mechanisms

MP Domogalla