The renin-angiotensin-aldosterone system plays crucial roles in cardiovascular physiology
and pathophysiology. However, many of the signaling mechanisms have been unclear. The …

There are many differences in arterial diseases between men and women, including
prevalence, clinical manifestations, treatments, and prognosis. The new policy of the …

The maintenance of appropriate arterial tone is critically important for normal physiological
arterial function. However, the cellular and molecular mechanisms remain poorly defined …

Background Metabolic disorders such as obesity, insulin resistance and type 2 diabetes
mellitus (DM2) are all linked to diabetic cardiomyopathy that lead to heart failure …

Vascular smooth muscle cells (vSMCs) play a crucial role in both the pathogenesis of
Aneurysms and Dissections of the ascending thoracic aorta (TAAD) in humans and in the …

Wu et al The RAS and Cardiovascular Functions e109 homocysteine decreased
antihypertensive effect of enalapril, an ACE inhibitor, in chronic hypertensive patients. 61 …

Abdominal aortic aneurysms (AAA) are characterized by extensive extracellular matrix
(ECM) fragmentation and inflammation. However, the mechanisms by which these events …

Abdominal aortic aneurysm (AAA), a deadly vascular disease in human, is a chronic
degenerative process of the abdominal aorta. In this process, inflammatory responses and …

A key aspect of genomic medicine is to make individualized clinical decisions from personal
genomes. We developed a machine-learning framework to integrate personal genomes and …

Adult vascular smooth muscle cells (VSMCs) dedifferentiate in response to extracellular
cues such as vascular damage and inflammation. Dedifferentiated VSMCs are proliferative …