While broad spectrum antibiotics play an invaluable role in the treatment of bacterial
infections, there are some drawbacks to their use, namely selection for and spread of …

Filamentous fungi arrange their cells in linear, coenocytic arrays, referred to as hyphae, that
extend at their tips and are able to branch and fuse, leading to a loose, three-dimensional …

The alarming rise of antimicrobial resistance requires antibiotics with unexploited
mechanisms. Ideal templates could be antibiotics that target the peptidoglycan precursor …

Conventional small‐molecule antibiotics are facing a significant challenge of the rapidly
developed drug resistance of pathogens. In contrast, antimicrobial peptides (AMPs), an …

Cyclic β-sheet decapeptides from the tyrocidine group and the homologous gramicidin S
were the first commercially used antibiotics, yet it remains unclear exactly how they kill …

We present the performance of HADDOCK, our information-driven docking software, in the
second edition of the D3R Grand Challenge. In this blind experiment, participants were …

The acylphloroglucinol rhodomyrtone is a promising new antibiotic isolated from the rose
myrtle Rhodomyrtus tomentosa, a plant used in Asian traditional medicine. While many …

Small cationic, amphipathic peptides with critical roles in host defenses often exhibit
overlapping but distinct immunomodulatory activity, direct antimicrobial activity towards …

What is a pathogen? What is a virulence factor? At one time, these were relatively
straightforward questions to address. During the late nineteenth century, when Pasteur and …

Introduction Resistance to traditional antibiotics is an increasingly serious problem.
Antimicrobial peptides (AMPs) have emerged as a new therapeutic class with great potential …