Single molecule localization microscopy coupled with touch preparation for the quantification of trastuzumab-bound HER2

SJ Tobin, DL Wakefield, V Jones, X Liu, D Schmolze… - Scientific reports, 2018 - nature.com
All breast cancers are assessed for levels of human epidermal growth factor receptor 2
(HER2). Fluorescence in situ hybridization (FISH) and immunohistochemistry are currently …

The novel dithiocarbamate, DpdtC suppresses HER2-overexpressed cancer cells by up-regulating NDRG1 via inactivation of HER2-ERK 1/2 signaling

Y Yang, Y Liu, R Guo, Y Fu, Z Zhang, P Zhang… - Scientific Reports, 2018 - nature.com
Dithiocarbamate has been tested for its effective anti-tumor activity, but the underlying
mechanism remains unclear. We previously prepared a novel diththiocarbamate derivative …

[HTML][HTML] Elucidation of the critical epitope of an anti-EGFR monoclonal antibody EMab-134

MK Kaneko, S Yamada, S Itai, YW Chang… - … and Biophysics Reports, 2018 - Elsevier
The epidermal growth factor receptor (EGFR) is a type-1 transmembrane receptor tyrosine
kinase, which activates the downstream signaling cascades in many tumors, such as oral …