The blood-brain barrier (BBB) prevents neurotoxic plasma components, blood cells, and
pathogens from entering the brain. At the same time, the BBB regulates transport of …

Epilepsy, a neurological disease characterized by recurrent seizures, is often associated
with a history of previous lesions in the nervous system. Impaired regulation of the activation …

Central nervous system (CNS) barriers predominantly mediate the immune-privileged status
of the brain, and are also important regulators of neuroimmune communication. It is …

Over the last decades, considerable efforts have been put into developing active nanocarrier
systems that cross the blood brain barrier (BBB) to treat brain-related diseases such as …

The brain is both the orchestrator as well as the target of the innate immune system's
response to the aseptic trauma of surgery. When trauma-induced inflammation is not …

The blood–brain barrier (BBB) is an important physiologic barrier that separates CNS from
soluble inflammatory mediators and effector immune cells from peripheral circulation. The …

The blood‐brain barrier (BBB) is a highly regulated interface that separates the peripheral
circulation and the brain. It plays a vital role in regulating the trafficking of solutes, fluid, and …

Brain mural cells form a heterogeneous family which significantly contributes to the
maintenance of the blood-brain barrier and regulation of the cerebral blood flow. Current …

Neuroinflammation is an essential mechanism involved in the pathogenesis of
subarachnoid hemorrhage (SAH)-induced brain injury. Recently, Netrin-1 (NTN-1) is well …

Extracellular matrix (ECM) proteins secreted by blood-brain barrier (BBB) endothelial cells
(ECs) are implicated in cell trafficking. We discovered that the expression of ECM epidermal …