Successful reprogramming of cellular protein production through mRNA delivered by functionalized lipid nanoparticles

M Yanez Arteta, T Kjellman… - Proceedings of the …, 2018 - National Acad Sciences
The development of safe and efficacious gene vectors has limited greatly the potential for
therapeutic treatments based on messenger RNA (mRNA). Lipid nanoparticles (LNPs) …

[图书][B] Surface and interfacial forces

HJ Butt, M Kappl - 2018 - books.google.com
A general introduction to surface and interfacial forces, perfectly combining theoretical
concepts, experimental techniques and practical applications. In this completely updated …

Transferable MARTINI model of poly (ethylene oxide)

F Grunewald, G Rossi, AH De Vries… - The journal of …, 2018 - ACS Publications
Motivated by the deficiencies of the previous MARTINI models of poly (ethylene
oxide)(PEO), we present a new model featuring a high degree of transferability. The model …

PEG-benzaldehyde-hydrazone-lipid based PEG-sheddable pH-sensitive liposomes: abilities for endosomal escape and long circulation

M Kanamala, BD Palmer, H Ghandehari… - Pharmaceutical …, 2018 - Springer
Purpose To fabricate an acid-cleavable PEG polymer for the development of PEG-cleavable
pH-sensitive liposomes (CL-pPSL), and to investigate their ability for endosomal escape and …

Out-of-the-groove transport of lipids by TMEM16 and GPCR scramblases

M Malvezzi, KK Andra, K Pandey… - Proceedings of the …, 2018 - National Acad Sciences
Phospholipid scramblases externalize phosphatidylserine to facilitate numerous
physiological processes. Several members of the structurally unrelated TMEM16 and G …

[HTML][HTML] Surface-grafted polyethylene glycol conformation impacts the transport of PEG-functionalized liposomes through a tumour extracellular matrix model

HI Labouta, MJ Gomez-Garcia, CD Sarsons… - RSC …, 2018 - pubs.rsc.org
The effect of surface PEGylation on nanoparticle transport through an extracellular matrix
(ECM) is an important determinant for tumor targeting success. Fluorescent stealth …

Morphology and physical properties of hydrophilic-polymer-modified lipids in supported lipid bilayers

Y Kakimoto, Y Tachihara, Y Okamoto, K Miyazawa… - Langmuir, 2018 - ACS Publications
Lipid molecules such as glycolipids that are modified with hydrophilic biopolymers
participate in the biochemical reactions occurring on cell membranes. Their functions and …

Effects of 1-hexanol on C 12 E 10 micelles: a molecular simulations and light scattering study

S Vierros, M Sammalkorpi - Physical Chemistry Chemical Physics, 2018 - pubs.rsc.org
The micelles of the non-ionic C12E10 surfactant and 1-hexanol as an aqueous solution
additives are studied toward the purpose of understanding the role of alcohol additives in …

Preserving the inflated structure of lyophilized sporopollenin exine capsules with polyethylene glycol osmolyte

MK Corliss, CK Bok, J Gillissen, MG Potroz… - Journal of industrial and …, 2018 - Elsevier
Extracted from natural pollen grains, sporopollenin exine capsules (SECs) are robust,
chemically inert biopolymer shells that posess highly uniform size and shape characteristics …

[HTML][HTML] Archaeal tetraether lipid coatings—A strategy for the development of membrane analog spacer systems for the site-specific functionalization of medical …

K Liefeith, M Frant, U Müller, P Stenstad, H Johnsen… - …, 2018 - pubs.aip.org
The primary goal of our investigation was the development of a versatile immobilization
matrix based on archaeal tetraether lipids that meets the most important prerequisites to …