Dementia is a clinical syndrome wherein gradual decline of mental and cognitive
capabilities of an afflicted person takes place. Dementia is associated with various risk …

Alzheimer's disease (AD) is characterized by cognitive inability manifested due to the
accumulation of β-amyloid, formation of hyper phosphorylated neurofibrillary tangles, and a …

The enzymatic activity of butyrylcholinesterase (BChE) in the brain increases with the
progression of Alzheimer's disease, thus classifying BChE as a promising drug target in …

Amaryllidaceae plants are the commercial source of galanthamine, an alkaloid approved for
the clinical treatment of Alzheimer's disease. The chemistry and bioactivity of Chilean …

The discovery of acetylcholine and acetylcholinesterase provided the first insight into the
intricacies of chemical signal transduction and neuronal communication. Further elucidation …

Background: As the number of elderly persons increases, neurodegenerative diseases are
becoming ubiquitous. There is currently a great need for knowledge concerning …

In the current study, a series of new ligustrazine‐based chalcones was synthesized. For
insertion of tetramethylpyrazine (TMP, also designated as ligustrazine) in chemical …

ABSTRACT Introduction: Butyrylcholinesterase (BuChE) has obtained a renewed interest as
therapeutic target in Alzheimer's disease (AD), when changes in BuChE activity and …

A small library of 17 organoruthenium compounds with the general formula [RuII
(fcl)(chel)(L)] n+ (in which fcl= face capping ligand, chel= chelating bidentate ligand, and L …

As an extension of our previous work on donepezil-based “bio-oxidizable” prodrug
approach, two new classes of N-benzylpyridinium donepezil analogues in tetralone B2 and …