[HTML][HTML] Targeted pituitary adenylate cyclase-activating peptide therapies for migraine

ALH Vollesen, FM Amin, M Ashina - Neurotherapeutics, 2018 - Elsevier
Here, we review the role of pituitary adenylate cyclase-activating peptide-38 (PACAP38) in
migraine pathophysiology and data implicating PAC 1 receptor as a future drug target in …

PACAP and its receptors in cranial arteries and mast cells

I Jansen-Olesen, S Hougaard Pedersen - The Journal of Headache and …, 2018 - Springer
Background In migraineurs pituitary adenylate cyclase activating peptide1–38 (PACAP1–
38) is a potent migraine provoking substance and the accompanying long lasting flushing …

PACAP neurons in the ventral premammillary nucleus regulate reproductive function in the female mouse

RA Ross, S Leon, JC Madara, D Schafer, C Fergani… - Elife, 2018 - elifesciences.org
Pituitary adenylate cyclase activating polypeptide (PACAP, Adcyap1) is a neuromodulator
implicated in anxiety, metabolism and reproductive behavior. PACAP global knockout mice …

Expression of pituitary adenylate cyclase-activating peptide, calcitonin gene-related peptide and headache targets in the trigeminal ganglia of rats and humans

SD Frederiksen, K Warfvinge, L Ohlsson, L Edvinsson - Neuroscience, 2018 - Elsevier
Neurotransmitter and headache target localization in the trigeminal ganglia (TG) might
increase the understanding of sites of action, and mechanisms related to headache therapy …

Review on PACAP-induced transcriptomic and proteomic changes in neuronal development and repair

A Rivnyak, P Kiss, A Tamas, D Balogh… - International journal of …, 2018 - mdpi.com
Pituitary adenylate cyclase activating polypeptide (PACAP) is a neuropeptide with
widespread occurrence and diverse biological effects. Among its several different effects, of …

Amnesiac is required in the adult mushroom body for memory formation

O Turrel, V Goguel, T Preat - Journal of Neuroscience, 2018 - Soc Neuroscience
It was proposed that the Drosophila amnesiac gene (amn) is required for consolidation of
aversive memory in the dorsal paired medial (DPM) neurons, a pair of large neurons that …

New insight into the control of peptic ulcer by targeting the histamine H2 receptor

V Singh, N Gohil… - Journal of Cellular …, 2018 - Wiley Online Library
Peptic ulcer disease is one of the major challenges in public health globally and new
evidence shows that it can be controlled by targeting the histamine H2 receptor (H2R) …

Impairment of microcirculation and vascular responsiveness in adolescents with primary Raynaud phenomenon

B Mosdósi, K Bölcskei, Z Helyes - Pediatric Rheumatology, 2018 - Springer
Background Raynaud's phenomenon (RP) is a functional vascular disease, presenting with
recurrent episodes of ischemia of extremities in response to cold and emotional stress …

Comparatively study on the insulin-regulated glucose homeostasis through brain-gut peptides in Japanese flounder Paralichthys olivaceus after intraperitoneal and …

D Liu, B Guo, D Han, K Deng, Z Gu, M Yang… - General and …, 2018 - Elsevier
The present study comparatively analyzed the blood glucose and insulin concentration, the
temporal and spatial expression of brain-gut peptides and the key enzymes of glycolysis and …

Grass carp prolactin gene: Structural characterization and signal transduction for PACAP-induced prolactin promoter activity

C Lin, J Bai, M He, AOL Wong - Scientific Reports, 2018 - nature.com
In this study, structural analysis of grass carp prolactin (PRL) gene was performed and the
signaling mechanisms for pituitary adenylate cyclase-activating peptide (PACAP) regulation …