Inhibition of GCN2 sensitizes ASNS-low cancer cells to asparaginase by disrupting the amino acid response
A Nakamura, T Nambu, S Ebara… - Proceedings of the …, 2018 - National Acad Sciences
General control nonderepressible 2 (GCN2) plays a major role in the cellular response to
amino acid limitation. Although maintenance of amino acid homeostasis is critical for tumor …
amino acid limitation. Although maintenance of amino acid homeostasis is critical for tumor …
A Novel l-Asparaginase with low l-Glutaminase Coactivity Is Highly Efficacious against Both T- and B-cell Acute Lymphoblastic Leukemias In Vivo
HA Nguyen, Y Su, JY Zhang, A Antanasijevic… - Cancer research, 2018 - AACR
Acute lymphoblastic leukemia (ALL) is the most common type of pediatric cancer, although
about 4 of every 10 cases occur in adults. The enzyme drug l-asparaginase serves as a …
about 4 of every 10 cases occur in adults. The enzyme drug l-asparaginase serves as a …
Systematic review of pharmacogenomics and adverse drug reactions in paediatric oncology patients
Many paediatric patients with cancer experience significant chemotherapy side effects.
Predisposition to drug reactions is governed by single nucleotide polymorphisms (SNPs) …
Predisposition to drug reactions is governed by single nucleotide polymorphisms (SNPs) …
Data integration for functional annotation of regulatory single nucleotide polymorphisms associated with Alzheimer's disease susceptibility
Background Alzheimer's disease (AD), the most common form of dementia affects 24.3
million people worldwide. More than twenty genetic loci have been associated with AD and …
million people worldwide. More than twenty genetic loci have been associated with AD and …
[HTML][HTML] Comparative study of the effect of atorvastatin and fenofibrate on high-density lipoprotein cholesterol levels in patients with type 2 diabetes
M Najafipour, M Zareizadeh, MA Khokhi… - Journal of Advanced …, 2018 - journals.lww.com
Diabetes is the most common metabolic disease. Type 2 diabetes is a variable combination
of insulin resistance and disorder in insulin secretion, leading to disorder of lipids and …
of insulin resistance and disorder in insulin secretion, leading to disorder of lipids and …