DNA methylation is currently the most promising molecular marker for monitoring aging and
predicting life expectancy. However, the mechanisms underlying age-related DNA …

DNA methylation plays important roles in gene expression regulation and chromatin
structure. Its proper establishment and maintenance are essential for mammalian …

MicroRNAs (miRNAs) are a class of small, non-coding RNAs that are involved in the
regulation of gene expression at the post-transcriptional level. MicroRNAs play an important …

Background Bisulfite sequencing is widely employed to study the role of DNA methylation in
disease; however, the data suffer from biases due to coverage depth variability. Imputation …

An adverse intrauterine environment is associated with long-term physiological changes in
offspring. These are believed to be mediated by epigenomic marks, including DNA …

Over the years, the epigenetic landscape has grown increasingly complex. Until recently,
methylation of DNA and histones was considered one of the most important epigenetic …

Following erasure in the blastocyst, the entire genome undergoes de novo methylation at
the time of implantation, with CpG islands being protected from this process. This bimodal …

Systemic anaplastic large-cell lymphoma (ALCL) is a childhood T cell neoplasm defined by
the presence or absence of translocations that lead to the ectopic expression of anaplastic …

2018-08-06 Assigned to NATIONAL INSTITUTES OF HEALTH (NIH), US DEPT. OF HEALTH
AND HUMAN SERVICES (DHHS), US GOVERNMENT reassignment NATIONAL …

Marek's disease is an oncogenic and lymphoproliferative disease of chickens caused by
Marek's disease virus. Hypermethylation or hypomethylation of CpG islands in gene …