Rapid-learning health systems have been proposed as a potential solution to the problem of
quality in medicine, by leveraging data generated from electronic health systems in near …

Advocates bring unique and important viewpoints to the cancer research process, ensuring
that scientific and medical advances are patient-centered and relevant. In this article, we …

Importance Radical cystectomy is the guidelines-recommended treatment of muscle-
invasive bladder cancer, but a resurgence of trimodal therapy has occurred. Limited …

Aim Because incidence of breast cancer and comorbidities increase with age, it is important
to determine treatment benefit in elderly patients. We evaluated outcomes with palbociclib …

Background Cardiovascular disease is the primary cause of death among patients with
breast cancer. However, the association of cardiovascular-disease risk factors (CVD-RFs) …

As part of the ongoing efforts to address the lack of clinical research on older adults with
cancer, the American Society of Clinical Oncology (ASCO) and the US Food and Drug …

Introduction Elderly patients account for the majority of lung cancer diagnoses but are poorly
represented in clinical trials. We evaluated the overall survival (OS) of elderly patients with …

Background: Older patients with multiple chronic conditions are often faced with increased
health care needs and subsequent higher medical costs, posing significant financial burden …

Abstract Purpose The 'Patient Reported Outcomes Following Initial treatment and Long-term
Evaluation of Survivorship'(PROFILES) registry collects patient-reported outcomes (PROs) …

Background There are multiple known individual‐and practice‐level barriers to enrollment of
older patients with cancer to clinical trials, but little is known about how the clinical research …