OPA1 is a GTPase that controls several functions, such as mitochondrial dynamics and
energetics, mtDNA maintenance and cristae integrity. In the last years, there have been …

Dysfunctions in mitochondrial dynamics and metabolism are common pathological
processes associated with Parkinson's disease (PD). It was recently shown that an inherited …

It is unclear how the mitochondrial fusion protein Optic atrophy 1 (OPA1), which inhibits
cristae remodeling, protects from mitochondrial dysfunction. Here we identify the …

Objectives To summarise and discuss recent findings and future perspectives concerning
mitochondrial disorders (MIDs) affecting the retinal ganglion cells and the optic nerve …

Background. Exercise benefits to cardiac rehabilitation (CR) following stable myocardial
infarction (MI). The suitable exercise duration for aged patients with coronary heart disease …

Potassium channels have been discovered in the inner mitochondrial membrane of various
cells. These channels can regulate the mitochondrial membrane potential, the matrix …

OPA1 is the major gene responsible for Dominant Optic Atrophy (DOA) and the syndromic
form DOA “plus”. Over 370 OPA1 mutations have been identified so far, although their …

Familial dysautonomia (FD) is an autosomal recessive disorder marked by developmental
and progressive neuropathies. It is caused by an intronic point-mutation in the IKBKAP/ELP1 …

Objective Defective mitochondrial function attributed to optic atrophy 1 (OPA1) mutations
causes primarily optic atrophy and, less commonly, neurodegenerative syndromes. The …

Mitochondrial morphology regulatory proteins interact with signaling pathways involved in
differentiation. In Drosophila oogenesis, EGFR signaling regulates mitochondrial …