Targeting cytokines to treat asthma and chronic obstructive pulmonary disease
PJ Barnes - Nature Reviews Immunology, 2018 - nature.com
Cytokines play a key role in orchestrating and perpetuating the chronic airway inflammation
in asthma and chronic obstructive pulmonary disease (COPD), making them attractive …
in asthma and chronic obstructive pulmonary disease (COPD), making them attractive …
[HTML][HTML] CXCL4/Platelet Factor 4 is an agonist of CCR1 and drives human monocyte migration
JM Fox, F Kausar, A Day, M Osborne, K Hussain… - Scientific reports, 2018 - nature.com
Activated platelets release micromolar concentrations of the chemokine CXCL4/Platelet
Factor-4. Deposition of CXCL4 onto the vascular endothelium is involved in atherosclerosis …
Factor-4. Deposition of CXCL4 onto the vascular endothelium is involved in atherosclerosis …
Pyrrolone derivatives as intracellular allosteric modulators for chemokine receptors: selective and dual-targeting inhibitors of CC chemokine receptors 1 and 2
NV Ortiz Zacarías, JPD van Veldhoven… - Journal of Medicinal …, 2018 - ACS Publications
The recent crystal structures of CC chemokine receptors 2 and 9 (CCR2 and CCR9) have
provided structural evidence for an allosteric, intracellular binding site. The high …
provided structural evidence for an allosteric, intracellular binding site. The high …
Evaluation of eosinophilic esophagitis
ME Rothenberg, C Blanchard - US Patent 10,155,985, 2018 - Google Patents
BACKGROUND Patients with eosinophilic esophagitis may have symptoms that include
abdominal pain, difficulty swallowing, vomiting, failure to thrive and weight loss. In addition …
abdominal pain, difficulty swallowing, vomiting, failure to thrive and weight loss. In addition …
[PDF][PDF] Investigation into the mechanisms of platelet recruitment and migration during allergic inflammation
SA Shah - 2018 - kclpure.kcl.ac.uk
A dichotomy in platelet activation has been described, where along with well-known
thrombotic and haemostatic responses, platelets can be activated via alternate pathways …
thrombotic and haemostatic responses, platelets can be activated via alternate pathways …
[PDF][PDF] The road to Insurmountability: Novel avenues to better target CC Chemokine Receptors
NV Ortiz Zacarías - Journal of Medicinal …, 2018 - scholarlypublications …
The recent crystal structures of CC chemokine receptors 2 and 9 (CCR2 and CCR9) have
provided structural evidence for an allosteric, intracellular binding site. The high …
provided structural evidence for an allosteric, intracellular binding site. The high …
[引用][C] Eosinophils on trial
JE Pease, TJ Williams - Clinical & Experimental Allergy, 2018 - Wiley Online Library
Although eosinophils constitute a minor population of blood granulocytes, they are recruited
in significant numbers at tissue sites of worm infection and allergic reactions. These cells …
in significant numbers at tissue sites of worm infection and allergic reactions. These cells …