This review offers a systematic understanding about how polyphenols target multiple
inflammatory components and lead to anti-inflammatory mechanisms. It provides a clear …

In recent years, the understanding of regulatory T cell (Treg cell) biology has expanded
considerably. Key observations have challenged the traditional definition of Treg cells and …

While many genetic variants have been associated with risk for human diseases, how these
variants affect gene expression in various cell types remains largely unknown. To address …

Advances in single-cell RNA sequencing (scRNA-seq) have allowed for comprehensive
analysis of the immune system. In this Review, we briefly describe the available scRNA-seq …

Checkpoint blockade immunotherapy is promising for clinical treatment of various malignant
tumors. However, checkpoint blockade immunotherapy suffers from a low response rate due …

Adoptive cell therapy of solid tumors with reprogrammed T cells can be considered the “next
generation” of cancer hallmarks. CAR-T cells fail to be as effective as in liquid tumors for the …

Mounting evidence suggests that aberrations in immune-inflammatory pathways contribute
to the pathophysiology of major depressive disorder (MDD), and individuals with MDD may …

Vaccines to induce effective and sustained antitumor immunity have great potential for
postoperative cancer therapy. However, a robust cancer vaccine simultaneously eliciting …

Purpose: We have shown that the aged microenvironment increases melanoma metastasis,
and decreases response to targeted therapy, and here we queried response to anti-PD1 …

Naïve CD4 T cells, on activation, differentiate into distinct T helper (Th) subsets that produce
lineage-specific cytokines. By producing unique sets of cytokines, effector Th subsets play …