Discovery of benzimidazole‐based Leishmania mexicana cysteine protease CPB2.8ΔCTE inhibitors as potential therapeutics for leishmaniasis
L De Luca, S Ferro, MR Buemi… - Chemical biology & …, 2018 - Wiley Online Library
Chemotherapy is currently the only effective approach to treat all forms of leishmaniasis.
However, its effectiveness is severely limited due to high toxicity, long treatment length, drug …
However, its effectiveness is severely limited due to high toxicity, long treatment length, drug …
New aziridine-based inhibitors of cathepsin L-like cysteine proteases with selectivity for the Leishmania cysteine protease LmCPB2. 8
P Fey, R Chartomatsidou, W Kiefer, JC Mottram… - European Journal of …, 2018 - Elsevier
In the present work a series of aziridine-2, 3-dicarboxylate inhibitors of papain-like cysteine
proteases was designed, synthesized and tested. The compounds displayed selectivity for …
proteases was designed, synthesized and tested. The compounds displayed selectivity for …
Ensemble‐based ADME–Tox profiling and virtual screening for the discovery of new inhibitors of the Leishmania mexicana cysteine protease CPB2.8ΔCTE
A Scala, A Rescifina, N Micale… - Chemical Biology & …, 2018 - Wiley Online Library
In an effort to identify novel molecular warheads able to inhibit Leishmania mexicana
cysteine protease CPB2. 8ΔCTE, fused benzo [b] thiophenes and β, βʹ‐triketones emerged …
cysteine protease CPB2. 8ΔCTE, fused benzo [b] thiophenes and β, βʹ‐triketones emerged …