Global aetiology and epidemiology of type 2 diabetes mellitus and its complications
Globally, the number of people with diabetes mellitus has quadrupled in the past three
decades, and diabetes mellitus is the ninth major cause of death. About 1 in 11 adults …
decades, and diabetes mellitus is the ninth major cause of death. About 1 in 11 adults …
Metformin as an anticancer agent
A Vancura, P Bu, M Bhagwat, J Zeng… - Trends in pharmacological …, 2018 - cell.com
Metformin has been a frontline therapy for type 2 diabetes (T2D) for many years. Its
effectiveness in T2D treatment is mostly attributed to its suppression of hepatic …
effectiveness in T2D treatment is mostly attributed to its suppression of hepatic …
Trends in cause-specific mortality among adults with and without diagnosed diabetes in the USA: an epidemiological analysis of linked national survey and vital …
Background Large reductions in diabetes complications have altered diabetes-related
morbidity in the USA. It is unclear whether similar trends have occurred in causes of death …
morbidity in the USA. It is unclear whether similar trends have occurred in causes of death …
Glucose-regulated phosphorylation of TET2 by AMPK reveals a pathway linking diabetes to cancer
Diabetes is a complex metabolic syndrome that is characterized by prolonged high blood
glucose levels and frequently associated with life-threatening complications …
glucose levels and frequently associated with life-threatening complications …
[HTML][HTML] Retracted: Worldwide burden of cancer attributable to diabetes and high body-mass index: a comparative risk assessment
Background Diabetes and high body-mass index (BMI) are associated with increased risk of
several cancers, and are increasing in prevalence in most countries. We estimated the …
several cancers, and are increasing in prevalence in most countries. We estimated the …
Diabetes, obesity, and breast cancer
C Kang, D LeRoith, EJ Gallagher - Endocrinology, 2018 - academic.oup.com
The rates of obesity and diabetes are increasing worldwide, whereas the age of onset for
both obesity and diabetes are decreasing steadily. Obesity and diabetes are associated with …
both obesity and diabetes are decreasing steadily. Obesity and diabetes are associated with …
Physical activity and cancer: an umbrella review of the literature including 22 major anatomical sites and 770 000 cancer cases
Objective To provide an overview of the breadth and validity of claimed associations
between physical activity and risk of developing or dying from cancer. Design Umbrella …
between physical activity and risk of developing or dying from cancer. Design Umbrella …
[PDF][PDF] Hypoxia‐inducible factor‐1α/interleukin‐1β signaling enhances hepatoma epithelial–mesenchymal transition through macrophages in a hypoxic‐inflammatory …
J Zhang, Q Zhang, Y Lou, Q Fu, Q Chen, T Wei… - …, 2018 - Wiley Online Library
The development and progression of hepatocellular carcinoma (HCC) are dependent on its
local microenvironment. Hypoxia and inflammation are two critical factors that shape the …
local microenvironment. Hypoxia and inflammation are two critical factors that shape the …
[HTML][HTML] The influence of diet on anti-cancer immune responsiveness
L Soldati, L Di Renzo, E Jirillo, PA Ascierto… - Journal of translational …, 2018 - Springer
Immunotherapy has matured into standard treatment for several cancers, but much remains
to be done to extend the reach of its effectiveness particularly to cancers that are resistant …
to be done to extend the reach of its effectiveness particularly to cancers that are resistant …
[HTML][HTML] Activation of Nrf2 signaling by natural products-can it alleviate diabetes?
M Matzinger, K Fischhuber, EH Heiss - Biotechnology advances, 2018 - Elsevier
Type 2 diabetes mellitus (DM) has reached pandemic proportions and effective prevention
strategies are wanted. Its onset is accompanied by cellular distress, the nuclear factor …
strategies are wanted. Its onset is accompanied by cellular distress, the nuclear factor …