Strategies for combating bacterial biofilms: A focus on anti-biofilm agents and their mechanisms of action

R Roy, M Tiwari, G Donelli, V Tiwari - Virulence, 2018 - Taylor & Francis
Biofilm refers to the complex, sessile communities of microbes found either attached to a
surface or buried firmly in an extracellular matrix as aggregates. The biofilm matrix …

[HTML][HTML] Extracellular polymeric substances, a key element in understanding biofilm phenotype

P Di Martino - AIMS microbiology, 2018 - ncbi.nlm.nih.gov
One of the key elements in the establishment and maintenance of the biofilm structure and
properties is the extracellular matrix. The extracellular matrix is composed of water and …

Genome-centered metagenomics analysis reveals the symbiotic organisms possessing ability to cross-feed with anammox bacteria in anammox consortia

Y Zhao, S Liu, B Jiang, Y Feng, T Zhu… - … science & technology, 2018 - ACS Publications
Although using anammox communities for efficient wastewater treatment has attracted much
attention, the pure anammox bacteria are difficult to obtain, and the potential roles of …

Recent developments in smart antibacterial surfaces to inhibit biofilm formation and bacterial infections

X Li, B Wu, H Chen, K Nan, Y Jin, L Sun… - Journal of materials …, 2018 - pubs.rsc.org
Since their development over 70 years, antibiotics are still the most effective strategy to treat
bacterial biofilms and infections. However, the overuse of antibiotics in human healthcare …

Potential targets for next generation antimicrobial glycoconjugate vaccines

F Micoli, P Costantino, R Adamo - FEMS microbiology reviews, 2018 - academic.oup.com
Cell surface carbohydrates have been proven optimal targets for vaccine development.
Conjugation of polysaccharides to a carrier protein triggers a T-cell-dependent immune …

[HTML][HTML] Targeted disruption of the extracellular polymeric network of Pseudomonas aeruginosa biofilms by alginate oligosaccharides

LC Powell, MF Pritchard, EL Ferguson… - npj Biofilms and …, 2018 - nature.com
Acquisition of a mucoid phenotype by Pseudomonas sp. in the lungs of cystic fibrosis (CF)
patients, with subsequent over-production of extracellular polymeric substance (EPS), plays …

Recent perspectives on the molecular basis of biofilm formation by Pseudomonas aeruginosa and approaches for treatment and biofilm dispersal

S Skariyachan, VS Sridhar, S Packirisamy… - Folia microbiologica, 2018 - Springer
Pseudomonas aeruginosa, a Gram-negative, rod-shaped bacterium causes widespread
diseases in humans. This bacterium is frequently related to nosocomial infections such as …

Biofilm formation–what we can learn from recent developments

T Bjarnsholt, K Buhlin, YF Dufrêne… - Journal of internal …, 2018 - Wiley Online Library
Although biofilms have been observed early in the history of microbial research, their impact
has only recently been fully recognized. Biofilm infections, which contribute to up to 80% of …

CdrA interactions within the Pseudomonas aeruginosa biofilm matrix safeguard it from proteolysis and promote cellular packing

C Reichhardt, C Wong, D Passos da Silva, DJ Wozniak… - MBio, 2018 - Am Soc Microbiol
Biofilms are robust multicellular aggregates of bacteria that are encased in an extracellular
matrix. Different bacterial species have been shown to use a range of biopolymers to build …

[HTML][HTML] Pseudomonas aeruginosa rugose small-colony variants evade host clearance, are hyper-inflammatory, and persist in multiple host environments

MJ Pestrak, SB Chaney, HC Eggleston… - PLoS …, 2018 - journals.plos.org
Pseudomonas aeruginosa causes devastating infections in immunocompromised
individuals. Once established, P. aeruginosa infections become incredibly difficult to treat …