[HTML][HTML] Acetaminophen toxicity: novel insights into mechanisms and future perspectives
A Ramachandran, H Jaeschke - Gene expression, 2018 - ncbi.nlm.nih.gov
Acetaminophen (APAP) overdose is the most common cause of acute liver failure in the US,
and decades of intense study of its pathogenesis resulted in the development of the antidote …
and decades of intense study of its pathogenesis resulted in the development of the antidote …
[HTML][HTML] Mitochondrial dysfunction as a mechanism of drug-induced hepatotoxicity: current understanding and future perspectives
A Ramachandran, RGJ Visschers, L Duan… - Journal of clinical and …, 2018 - ncbi.nlm.nih.gov
Mitochondria are critical cellular organelles for energy generation and are now also
recognized as playing important roles in cellular signaling. Their central role in energy …
recognized as playing important roles in cellular signaling. Their central role in energy …
[HTML][HTML] Dissecting the molecular pathophysiology of drug-induced liver injury
H Ye, LJ Nelson, MG Del Moral… - World journal of …, 2018 - ncbi.nlm.nih.gov
Drug-induced liver injury (DILI) has become a major topic in the field of Hepatology and
Gastroenterology. DILI can be clinically divided into three phenotypes: hepatocytic …
Gastroenterology. DILI can be clinically divided into three phenotypes: hepatocytic …
Hepatoprotective Effect of Polysaccharides Isolated from Dendrobium officinale against Acetaminophen‐Induced Liver Injury in Mice via Regulation of the Nrf2 …
G Lin, D Luo, J Liu, X Wu, J Chen… - Oxidative Medicine …, 2018 - Wiley Online Library
The effect of polysaccharides isolated from Dendrobium officinale (DOP) on acetaminophen‐
(APAP‐) induced hepatotoxicity and the underlying mechanisms involved are investigated …
(APAP‐) induced hepatotoxicity and the underlying mechanisms involved are investigated …
Spatio-temporal visualization of the distribution of acetaminophen as well as its metabolites and adducts in mouse livers by MALDI MSI
Acetaminophen (APAP) is one of the most intensively studied compounds that causes
hepatotoxicity in the pericentral region of the liver lobules. However, spatio-temporal …
hepatotoxicity in the pericentral region of the liver lobules. However, spatio-temporal …
Natural dietary pigments: potential mediators against hepatic damage induced by over-the-counter non-steroidal anti-inflammatory and analgesic drugs
HA González-Ponce, AR Rincón-Sánchez… - Nutrients, 2018 - mdpi.com
Over-the-counter (OTC) analgesics are among the most widely prescribed and purchased
drugs around the world. Most analgesics, including non-steroidal anti-inflammatory drugs …
drugs around the world. Most analgesics, including non-steroidal anti-inflammatory drugs …
Adverse effects of two pharmaceuticals acetaminophen and oxytetracycline on life cycle parameters, oxidative stress, and defensome system in the marine rotifer …
To investigate the adverse effect of two widely used pharmaceuticals, paracetamol
(acetaminophen [APAP]) and oxytetracycline (OTC) on the marine rotifer Brachionus …
(acetaminophen [APAP]) and oxytetracycline (OTC) on the marine rotifer Brachionus …
Structure-activity and structure-property relationships of novel Nrf2 activators with a 1, 2, 4-oxadiazole core and their therapeutic effects on acetaminophen (APAP) …
LL Xu, YF Wu, L Wang, CC Li, L Li, B Di, QD You… - European Journal of …, 2018 - Elsevier
The antioxidant function induced by Nrf2 protects the liver from damage. We found a novel
Nrf2 activator named compound 25 via structural modification of compound 1 we previously …
Nrf2 activator named compound 25 via structural modification of compound 1 we previously …
Comparison of hepatic transcriptome profiling between acute liver injury and acute liver failure induced by acetaminophen in mice
C Li, Y Ming, W Hong, Y Tang, X Lei, X Li, Y Mao - Toxicology letters, 2018 - Elsevier
Acetaminophen (APAP) overdose is a leading cause of drug-induced acute liver failure in
many countries. In the present study, we developed stable mouse models of acute drug …
many countries. In the present study, we developed stable mouse models of acute drug …
Shikonin attenuates acetaminophen-induced hepatotoxicity by upregulation of Nrf2 through Akt/GSK3β signaling
H Li, Y Chen, J Zhang, X Chen, Z Li, B Liu, L Zhang - Molecules, 2018 - mdpi.com
Acetaminophen (APAP) overdose-induced acute liver damage is mostly due to
overwhelmingly increased oxidative stress. Nuclear factor-erythroid 2-related factor2 (Nrf2) …
overwhelmingly increased oxidative stress. Nuclear factor-erythroid 2-related factor2 (Nrf2) …