Resistant hypertension (RH) is defined as above-goal elevated blood pressure (BP) in a
patient despite the concurrent use of 3 antihypertensive drug classes, commonly including a …

ADAMTS proteins are a superfamily of 26 secreted molecules comprising two related, but
distinct families. ADAMTS proteases are zinc metalloendopeptidases, most of whose …

Stroke has multiple etiologies, but the underlying genes and pathways are largely unknown.
We conducted a multiancestry genome-wide-association meta-analysis in 521,612 …

High blood pressure is a highly heritable and modifiable risk factor for cardiovascular
disease. We report the largest genetic association study of blood pressure traits (systolic …

Genome-wide association studies of birth weight have focused on fetal genetics, whereas
relatively little is known about the role of maternal genetic variation. We aimed to identify …

Bevacizumab is a vascular endothelial growth factor-A-specific angiogenesis inhibitor
indicated as an adjunct to chemotherapy for the treatment of several types of cancer …

Genetic factors predictive of severe adolescent idiopathic scoliosis (AIS) are largely
unknown. To identify genetic variation associated with severe AIS, we performed an exome …

Worldwide, hypertension still represents a serious health burden with nine million people
dying as a consequence of hypertension-related complications. Essential hypertension is a …

Hypertension (HTN) is a complex multi-factorial disease and is considered one of the
foremost modifiable risk factors for stroke, heart failure, ischemic heart disease and renal …

There is a long way from the initial discovery of a genome‐wide significant signal to
mechanistic understanding of the association. Identification of the gene and causal …