Immunological mechanisms of human resistance to persistent Mycobacterium tuberculosis infection

JD Simmons, CM Stein, C Seshadri, M Campo… - Nature Reviews …, 2018 - nature.com
Mycobacterium tuberculosis is a leading cause of mortality worldwide and establishes a
long-lived latent infection in a substantial proportion of the human population. Multiple lines …

Revisiting the timetable of tuberculosis

MA Behr, PH Edelstein, L Ramakrishnan - Bmj, 2018 - bmj.com
Revisiting the timetable of tuberculosis Page 1 Revisiting the timetable of tuberculosis OPEN
ACCESS Tuberculosis has a much shorter incubation period than is widely thought, say Marcel …

A systematic review of adverse events of rifapentine and isoniazid compared to other treatments for latent tuberculosis infection

C Pease, B Hutton, F Yazdi, D Wolfe… - … and drug safety, 2018 - Wiley Online Library
Purpose Tuberculosis (TB) remains a common cause of death globally. A regimen of 12
doses of isoniazid (INH) and rifapentine given once weekly (INH/RPT‐3) has recently been …

Metabolite changes in blood predict the onset of tuberculosis

J Weiner 3rd, J Maertzdorf, JS Sutherland… - Nature …, 2018 - nature.com
New biomarkers of tuberculosis (TB) risk and disease are critical for the urgently needed
control of the ongoing TB pandemic. In a prospective multisite study across Subsaharan …

TB preventive therapy for people living with HIV: key considerations for scale-up in resource-limited settings

I Pathmanathan, S Ahmedov, E Pevzner… - … of Tuberculosis and …, 2018 - ingentaconnect.com
Tuberculosis (TB) is the leading cause of death for persons living with the human
immunodeficiency virus (PLHIV). TB preventive therapy (TPT) works synergistically with, and …

Tuberculosis control interventions targeted to previously treated people in a high-incidence setting: a modelling study

FM Marx, R Yaesoubi, NA Menzies… - The Lancet Global …, 2018 - thelancet.com
Background In high-incidence settings, recurrent disease among previously treated
individuals contributes substantially to the burden of incident and prevalent tuberculosis …

Determinants of tuberculosis trends in six Indigenous populations of the USA, Canada, and Greenland from 1960 to 2014: a population-based study

K Dehghani, Z Lan, P Li, SW Michelsen… - The Lancet Public …, 2018 - thelancet.com
Background Tuberculosis continues to disproportionately affect many Indigenous
populations in the USA, Canada, and Greenland. We aimed to investigate whether …

Tackling injustices of occupational lung disease acquired in South African mines: recent developments and ongoing challenges

B Kistnasamy, A Yassi, J Yu, SJ Spiegel, A Fourie… - Globalization and …, 2018 - Springer
Abstract Background South Africa's mineral resources have produced, and continue to
produce, enormous economic wealth; yet decades of colonialism, apartheid, capital flight …

[HTML][HTML] Considerations for biomarker-targeted intervention strategies for tuberculosis disease prevention

A Fiore-Gartland, LN Carpp, K Naidoo, E Thompson… - Tuberculosis, 2018 - Elsevier
Current diagnostic tests for Mycobacterium tuberculosis (MTB) infection have low prognostic
specificity for identifying individuals who will develop tuberculosis (TB) disease, making …

Where is tuberculosis transmission happening? Insights from the literature, new tools to study transmission and implications for the elimination of tuberculosis

SC Auld, NS Shah, T Cohen, NA Martinson… - …, 2018 - Wiley Online Library
More than 10 million new cases of tuberculosis (TB) are diagnosed worldwide each year.
The majority of these cases occur in low‐and middle‐income countries where the TB …