Bromodomain and extraterminal domain (BET) proteins are epigenetic readers that regulate
gene expression and are involved in cancer pathogenesis. Over the last years, several BET …

Cancer cells rely on dysregulated gene expression. This establishes specific transcriptional
addictions that may be therapeutically exploited. Yet, the mechanisms that are ultimately …

Alzheimer's disease (AD) is the most important neurodegenerative disorder in Western
countries. Pathological phenotypes of neurodegeneration result from a combination of …

Proteins of the bromodomain and extra-terminal (BET) family are epigenetics “readers” and
promising therapeutic targets for cancer and other human diseases. We describe herein a …

The bromodomain and extra-terminal domain (BET) family of proteins bind acetylated lysine
residues on histone proteins. The four BET bromodomains—BRD2, BRD3, BRD4, and …

CTLA-4 is an immune checkpoint expressed on active anticancer T cells. When it combines
with its ligand B7 on dendritic cells, it inhibits the activity of the T cells. The Bromo-and Extra …

As regulators of transcription, epigenetic proteins that interpret post-translational
modifications to N-terminal histone tails are essential for maintaining cellular homeostasis …

Developmental transitions are guided by master regulatory transcription factors. During
adipogenesis, a transcriptional cascade culminates in the expression of PPARγ and …

Alkaline phosphatases (APs) remove the phosphate (dephosphorylation) needed in multiple
metabolic processes (from many molecules such as proteins, nucleotides, or …

Cerebrovascular and neurodegenerative disorders affect one billion people around the
world and result from a combination of genomic, epigenomic, metabolic, and environmental …