In the past decade, significant progress has been made in complex disease research across
multiple omics layers from genome, transcriptome and proteome to metabolome. There is an …

The genetic architecture of brain structure and function is largely unknown. To investigate
this, we carried out genome-wide association studies of 3,144 functional and structural brain …

Alzheimer's disease (AD) is a leading cause of mortality among the elderly. We performed a
whole-genome sequencing study of AD in the Chinese population. In addition to the variants …

Identifying genetic risk factors underpinning different aspects of Alzheimer's disease has the
potential to provide important insights into pathogenesis. Moving away from simple case …

Introduction Genetic associations for endophenotypes of Alzheimer's disease (AD) in
cognitive stages preceding AD have not been thoroughly evaluated. Methods We conducted …

Background Contralateral brain structures represent a unique, within-patient reference
element for disease, and asymmetries can provide a personalized measure of the …

Brain-wide and genome-wide association (BW-GWA) study is presented in this paper to
identify the associations between the brain imaging phenotypes (ie, regional volumetric …

Genome-wide association studies have identified several cholesterol metabolism–related
genes as top risk factors for late-onset Alzheimer's disease (LOAD). We hypothesized that …

Background APOE ε4 allele is most common genetic risk factor for Alzheimer's disease (AD)
and cognitive decline. However, it remains poorly understood why only some carriers of …

Motivation Brain imaging genetics, which studies the linkage between genetic variations and
structural or functional measures of the human brain, has become increasingly important in …