BMPR2 mutations and endothelial dysfunction in pulmonary arterial hypertension (2017 Grover Conference Series)
A Frump, A Prewitt… - Pulmonary circulation, 2018 - journals.sagepub.com
Despite the discovery more than 15 years ago that patients with hereditary pulmonary
arterial hypertension (HPAH) inherit BMP type 2 receptor (BMPR2) mutations, it is still …
arterial hypertension (HPAH) inherit BMP type 2 receptor (BMPR2) mutations, it is still …
Dominant role for regulatory T cells in protecting females against pulmonary hypertension
R Tamosiuniene, O Manouvakhova… - Circulation …, 2018 - Am Heart Assoc
Rationale: Pulmonary arterial hypertension (PH) is a life-threatening condition associated
with immune dysregulation and abnormal regulatory T cell (Treg) activity, but it is currently …
with immune dysregulation and abnormal regulatory T cell (Treg) activity, but it is currently …
Twist1 in hypoxia-induced pulmonary hypertension through transforming growth factor-β–Smad signaling
T Mammoto, M Muyleart, GG Konduri… - American journal of …, 2018 - atsjournals.org
Pulmonary hypertension (PH) is a devastating pulmonary vascular disease characterized by
aberrant muscularization of the normally nonmuscularized distal pulmonary arterioles. The …
aberrant muscularization of the normally nonmuscularized distal pulmonary arterioles. The …
Current knowledge and recent advances of right ventricular molecular biology and metabolism from congenital heart disease to chronic pulmonary hypertension
S Guimaron, J Guihaire, M Amsallem… - BioMed Research …, 2018 - Wiley Online Library
Studies about pulmonary hypertension and congenital heart diseases have introduced the
concept of right ventricular remodeling leading these pathologies to a similar outcome: right …
concept of right ventricular remodeling leading these pathologies to a similar outcome: right …
Baicalein attenuates monocrotaline-induced pulmonary arterial hypertension by inhibiting vascular remodeling in rats
R Shi, Z Wei, D Zhu, N Fu, C Wang, S Yin… - Pulmonary …, 2018 - Elsevier
Background Pulmonary arterial hypertension (PAH) is a devastating cardiopulmonary
disorder characterized by elevated pulmonary arterial pressure (PAP) and right ventricular …
disorder characterized by elevated pulmonary arterial pressure (PAP) and right ventricular …
[HTML][HTML] Sex differences in hemodynamic responses and long-term survival to optimal medical therapy in patients with pulmonary arterial hypertension
K Kozu, K Sugimura, T Aoki, S Tatebe, S Yamamoto… - Heart and vessels, 2018 - Springer
It is widely known that the incidence of pulmonary arterial hypertension (PAH) is higher in
female, whereas prognosis is poorer in male patients. However, sex differences in …
female, whereas prognosis is poorer in male patients. However, sex differences in …
[HTML][HTML] EP4 agonist L-902,688 suppresses EndMT and attenuates right ventricular cardiac fibrosis in experimental pulmonary arterial hypertension
YJ Lai, IC Chen, HH Li, CC Huang - International Journal of Molecular …, 2018 - mdpi.com
Right ventricular (RV) hypertrophy is characterized by cardiac fibrosis due to endothelial–
mesenchymal transition (EndMT) and increased collagen production in pulmonary arterial …
mesenchymal transition (EndMT) and increased collagen production in pulmonary arterial …
[HTML][HTML] Blood outgrowth and proliferation of endothelial colony forming cells are related to markers of disease severity in patients with pulmonary arterial hypertension
J Smits, D Tasev, S Andersen, R Szulcek… - International journal of …, 2018 - mdpi.com
In pulmonary arterial hypertension (PAH), lung-angioproliferation leads to increased
pulmonary vascular resistance, while simultaneous myocardial microvessel loss contributes …
pulmonary vascular resistance, while simultaneous myocardial microvessel loss contributes …
Early versus late cardiac remodeling during right ventricular pressure load and impact of preventive versus rescue therapy with endothelin-1 receptor blockers
SR Ramos, G Pieles, M Sun… - Journal of Applied …, 2018 - journals.physiology.org
Pulmonary artery banding (PAB) causes right ventricular (RV) dysfunction, biventricular
fibrosis, and apoptosis, which are attenuated by endothelin-1 receptor blockade (ERB). Little …
fibrosis, and apoptosis, which are attenuated by endothelin-1 receptor blockade (ERB). Little …
How does the pressure-overloaded right ventricle adapt and why does it fail? Macro-and micro-molecular perspectives
NF Voelkel - Right Ventricular Physiology, Adaptation and Failure in …, 2018 - Springer
The right ventricle (RV) eventually fails in most patients with severe chronic pulmonary
hypertension, however, the individual myocardial reserve and ability to cope with the …
hypertension, however, the individual myocardial reserve and ability to cope with the …