Genetic insights into the morass of metastatic heterogeneity
Tumour heterogeneity poses a substantial problem for the clinical management of cancer.
Somatic evolution of the cancer genome results in genetically distinct subclones in the …
Somatic evolution of the cancer genome results in genetically distinct subclones in the …
Combined Mutation of Apc, Kras, and Tgfbr2 Effectively Drives Metastasis of Intestinal Cancer
E Sakai, M Nakayama, H Oshima, Y Kouyama, A Niida… - Cancer research, 2018 - AACR
Colorectal cancer is driven by the accumulation of driver mutations, but the contributions of
specific mutations to different steps in malignant progression are not fully understood. In this …
specific mutations to different steps in malignant progression are not fully understood. In this …
The RAS mutation status predicts survival in patients undergoing hepatic resection for colorectal liver metastases: The results from a genetic analysis of all‐RAS
K Amikura, K Akagi, T Ogura… - Journal of surgical …, 2018 - Wiley Online Library
Introduction We investigated the impact of mutations in KRAS exons 3‐4 and NRAS exons 2‐
3 in addition to KRAS exon 2, so‐called all‐RAS mutations, in patients with colorectal liver …
3 in addition to KRAS exon 2, so‐called all‐RAS mutations, in patients with colorectal liver …
Impact of RAS Mutations in Metastatic Colorectal Cancer After Potentially Curative Resection: Does Site of Metastases Matter?
G Passot, BJ Kim, O Glehen, RJ Mehran… - Annals of surgical …, 2018 - Springer
Background RAS mutation status is an important prognostic factor after resection of liver
metastases (LiM) from colorectal cancer (CRC). The prognostic significance of RAS after …
metastases (LiM) from colorectal cancer (CRC). The prognostic significance of RAS after …
[HTML][HTML] Mutational profile of colorectal cancer lung metastases and paired primary tumors by targeted next generation sequencing: implications on clinical outcome …
T Schweiger, S Liebmann-Reindl… - Journal of Thoracic …, 2018 - ncbi.nlm.nih.gov
Background Pulmonary metastasectomy is one of the cornerstones in the treatment of
oligometastatic colorectal cancer (CRC). However, the selection of patients who benefit from …
oligometastatic colorectal cancer (CRC). However, the selection of patients who benefit from …
Associations between primary tumor RAS, BRAF and PIK3CA mutation status and metastatic site in patients with chemo-resistant metastatic colorectal cancer
TD Christensen, JA Palshof, FO Larsen… - Acta …, 2018 - Taylor & Francis
Background: Several studies have investigated correlations between metastatic pattern and
mutation status in patients with colorectal cancer (CRC). However, most of the studies were …
mutation status in patients with colorectal cancer (CRC). However, most of the studies were …
[HTML][HTML] Inducible intestine-specific expression of krasV12 triggers intestinal tumorigenesis in transgenic zebrafish
JW Lu, D Raghuram, PSA Fong, Z Gong - Neoplasia, 2018 - Elsevier
KRAS mutations are a major risk factor in colorectal cancers. In particular, a point mutation of
KRAS of amino acid 12, such as KRAS V12, renders it stable activity in oncogenesis. We …
KRAS of amino acid 12, such as KRAS V12, renders it stable activity in oncogenesis. We …
[HTML][HTML] Hotspot KRAS exon 2 mutations in CD166 positive colorectal cancer and colorectal adenoma cells
Colorectal cancer (CRC) is the third most common cancer and the fourth leading cause of
cancer deaths worldwide. Recent studies have shown that cancer stem cells (CSCs) are an …
cancer deaths worldwide. Recent studies have shown that cancer stem cells (CSCs) are an …
[PDF][PDF] Combined mutation of Apc, Kras and Tgfbr2 effectively drives metastasis of intestinal cancer
坂井絵梨 - 2018 - kanazawa-u.repo.nii.ac.jp
Colorectal cancer is driven by the accumulation of driver mutations, but the contributions of
specific mutations to different steps in malignant progression are not fully understood. In this …
specific mutations to different steps in malignant progression are not fully understood. In this …