Unraveling the role of angiogenesis in cancer ecosystems

I Zuazo-Gaztelu, O Casanovas - Frontiers in Oncology, 2018 - frontiersin.org
Activation of the tumor and stromal cell-driven angiogenic program is one of the first
requirements in the tumor ecosystem for growth and dissemination. The understanding of …

Biomechanical characterization at the cell scale: present and prospects

F Basoli, SM Giannitelli, M Gori, P Mozetic… - Frontiers in …, 2018 - frontiersin.org
The rapidly growing field of mechanobiology demands for robust and reproducible
characterization of cell mechanical properties. Recent achievements in understanding the …

Control of cell morphology and differentiation by substrates with independently tunable elasticity and viscous dissipation

EE Charrier, K Pogoda, RG Wells… - Nature communications, 2018 - nature.com
The mechanical properties of extracellular matrices can control the function of cells. Studies
of cellular responses to biomimetic soft materials have been largely restricted to hydrogels …

Bimodal sensing of guidance cues in mechanically distinct microenvironments

ED Tabdanov, VV Puram, Z Win, A Alamgir… - Nature …, 2018 - nature.com
Contact guidance due to extracellular matrix architecture is a key regulator of carcinoma
invasion and metastasis, yet our understanding of how cells sense guidance cues is limited …

Mechanisms linking mechanotransduction and cell metabolism

AM Salvi, KA DeMali - Current opinion in cell biology, 2018 - Elsevier
Throughout their lifetimes, all cells experience force. These forces are sensed by cell surface
adhesion receptors, such as the cadherins and integrins. Much attention has focused on …

Mechanoelectrical transduction in chondrocytes

MR Servin‐Vences, J Richardson… - Clinical and …, 2018 - Wiley Online Library
Cartilage tissue lines the joints of mammals, helping to lubricate joint movement and
distribute mechanical loads. This tissue is comprised of isolated cells known as …

Mechanotargeting: Mechanics‐Dependent Cellular Uptake of Nanoparticles

Q Wei, C Huang, Y Zhang, T Zhao, P Zhao… - Advanced …, 2018 - Wiley Online Library
Targeted delivery of nanoparticle (NP)‐based diagnostic and therapeutic agents to
malignant cells and tissues has exclusively relied on chemotargeting, wherein NPs are …

Vascular smooth muscle cells direct extracellular dysregulation in aortic stiffening of hypertensive rats

TT Hays, B Ma, N Zhou, S Stoll, WJ Pearce, H Qiu - Aging cell, 2018 - Wiley Online Library
Aortic stiffening is an independent risk factor that underlies cardiovascular morbidity in the
elderly. We have previously shown that intrinsic mechanical properties of vascular smooth …

Protein–substrate adhesion in microcontact printing regulates cell behavior

S Hu, TH Chen, Y Zhao, Z Wang, RHW Lam - Langmuir, 2018 - ACS Publications
Microcontact printing (μCP) is widely used to create patterns of biomolecules essential for
studies of cell mechanics, migration, and tissue engineering. However, different types of …

Nonlinear cellular mechanical behavior adaptation to substrate mechanics identified by atomic force microscope

K Mollaeian, Y Liu, S Bi, Y Wang, J Ren… - International journal of …, 2018 - mdpi.com
Cell–substrate interaction plays an important role in intracellular behavior and function.
Adherent cell mechanics is directly regulated by the substrate mechanics. However …