Aims The expression of GADD153 (growth arrest and DNA damage-inducible gene 153), an
apoptosis-regulated gene, increases during endoplasmic reticulum (ER) stress. How …

Background In the PATHWAY-2 study of resistant hypertension, spironolactone reduced
blood pressure substantially more than conventional antihypertensive drugs. We did three …

Abstract Purpose of Review In patients with prediabetes or type 2 diabetes, the use of
thiazides as antihypertensive agents has been challenged because associated metabolic …

Purpose Hypomagnesaemia has been associated with various adverse outcomes. Loop
and thiazide diuretics promote urinary magnesium excretion. However, it is unknown if this …

An HLA-DR3 association with membranous nephropathy (MN) was described in 1979 and
additional evidence for a genetic component to MN was suggested in 1984 in reports of …

High blood pressure accounts for more than 50% of deaths from stroke and ischemic heart
disease worldwide. Hypertensive cardiomyopathy, aortic stenosis, aortic syndromes, and …

Abstract Treatment of hypertension with thiazide diuretics may trigger hypokalemia,
hyperglycemia, and hyperuricemia. Some studies suggest simultaneous potassium …

Have they succeeded in giving Hypertension its 2020 vision? To some, it is a puzzle how
international guidelines can differ so much from each other. But given the variation in …

Prevention of blood pressure (BP) rising with age is the rational approach to prevent the
consequences of hypertension. This chapter provides recommendations supported by …

Abstract The first Health Survey England (HSE) was carried out in 12,117 people in 1994.1
Only 46% of those with hypertension had been diagnosed and only 32% were treated. 18 …