Multi-targetable chalcone analogs to treat deadly Alzheimer's disease: Current view and upcoming advice
X Zhang, KP Rakesh, SNA Bukhari, M Balakrishna… - Bioorganic …, 2018 - Elsevier
The complications of Alzheimer's disease AD were deadly dangerous cause of
neurodegenerative disorders connected with the decline of the cognitive functions and loss …
neurodegenerative disorders connected with the decline of the cognitive functions and loss …
Bridging type 2 diabetes and Alzheimer's disease: assembling the puzzle pieces in the quest for the molecules with therapeutic and preventive potential
AM de Matos, MP de Macedo… - Medicinal Research …, 2018 - Wiley Online Library
Abstract Type 2 diabetes (T2D) and Alzheimer's disease (AD) are two age‐related amyloid
diseases that affect millions of people worldwide. Broadly supported by epidemiological …
diseases that affect millions of people worldwide. Broadly supported by epidemiological …
Graphene-based enzyme-modified field-effect transistor biosensor for monitoring drug effects in Alzheimer's disease treatment
A reduced graphene oxide-based enzyme-modified field-effect transistor (RGO-EnFET) was
fabricated to study the enzymatic kinetics between acetylcholinesterase (AChE) and …
fabricated to study the enzymatic kinetics between acetylcholinesterase (AChE) and …
Design, synthesis and evaluation of novel bivalent β-carboline derivatives as multifunctional agents for the treatment of Alzheimer's disease
Y Zhao, F Ye, J Xu, Q Liao, L Chen, W Zhang… - Bioorganic & medicinal …, 2018 - Elsevier
To develop potent multi-target ligands against Alzheimer's disease (AD), a series of novel
bivalent β-carboline derivatives were designed, synthesized, and evaluated. In vitro studies …
bivalent β-carboline derivatives were designed, synthesized, and evaluated. In vitro studies …
Metformin and its sulphonamide derivative simultaneously potentiateanti-cholinesterase activity of donepezil and inhibit beta-amyloid aggregation
M Markowicz-Piasecka, KM Huttunen… - Journal of Enzyme …, 2018 - Taylor & Francis
The aim of this study was to assess in vitro the effects of sulphenamide and sulphonamide
derivatives of metformin on the activity of human acetylcholinesterase (AChE) and …
derivatives of metformin on the activity of human acetylcholinesterase (AChE) and …
Attenuation of aluminum-induced neurotoxicity by tannoid principles of Emblica officinalis in Wistar rats
MD Bharathi, AJ Thenmozhi - International Journal of Nutrition …, 2018 - journals.lww.com
Materials and Methods: Rats were randomly divided into four groups and treated with AlCl 3
(100 mg/kg, bwip), EoT (100 mg/kg, bw oral), and simultaneously with AlCl 3 and EoT daily …
(100 mg/kg, bwip), EoT (100 mg/kg, bw oral), and simultaneously with AlCl 3 and EoT daily …
Tricyclic pyrazolo [1, 5-d][1, 4] benzoxazepin-5 (6H)-one scaffold derivatives: synthesis and biological evaluation as selective BuChE inhibitors
SC Chen, GL Qiu, B Li, JB Shi, XH Liu… - European Journal of …, 2018 - Elsevier
BuChE inhibitors play important roles in treatment of patients with advanced Alzheimer's
disease (AD). A series of tricyclic pyrazolo [1, 5-d][1, 4] benzoxazepin-5 (6H)-one derivatives …
disease (AD). A series of tricyclic pyrazolo [1, 5-d][1, 4] benzoxazepin-5 (6H)-one derivatives …
Design, synthesis and biological evaluation of tricyclic pyrazolo[1,5-c][1,3]benzoxazin-5(5H)-one scaffolds as selective BuChE inhibitors
GL Qiu, SS He, SC Chen, B Li, HH Wu… - Journal of Enzyme …, 2018 - Taylor & Francis
Based on the structural analysis of tricyclic scaffolds as butyrylcholinesterase (BuChE)
inhibitors, a series of pyrazolo [1, 5-c][1, 3] benzoxazin-5 (5 H)-one derivatives were …
inhibitors, a series of pyrazolo [1, 5-c][1, 3] benzoxazin-5 (5 H)-one derivatives were …
Virtual screening in the search of new and potent anti-Alzheimer agents
L Basile - Computational modeling of drugs against Alzheimer's …, 2018 - Springer
Alzheimer's disease (AD) is a multifaceted neurodegenerative disorder for which there is no
cure, but only symptomatic drugs are available. Most of the scientific efforts are addressed …
cure, but only symptomatic drugs are available. Most of the scientific efforts are addressed …
[PDF][PDF] Isolation of flavonoides from Artemisia macrocephala anticholinesterase activity: Isolation, characterization and its in vitro anticholinesterse activity supported by …
In this study the flavonoids isolated from Artemisia macrocephala were screened out for
anticholinesterase activity. The isolated flvanoids were characterized by HNMR, NOESY …
anticholinesterase activity. The isolated flvanoids were characterized by HNMR, NOESY …