Current knowledge on exosome biogenesis and release

NP Hessvik, A Llorente - Cellular and Molecular Life Sciences, 2018 - Springer
Exosomes are nanosized membrane vesicles released by fusion of an organelle of the
endocytic pathway, the multivesicular body, with the plasma membrane. This process was …

Why the need and how to approach the functional diversity of extracellular vesicles

M Tkach, J Kowal, C Théry - … Transactions of the Royal …, 2018 - royalsocietypublishing.org
In the past decade, cell-to-cell communication mediated by exosomes has attracted growing
attention from biomedical scientists and physicians, leading to several recent publications in …

Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the …

C Théry, KW Witwer, E Aikawa… - Journal of …, 2018 - Wiley Online Library
The last decade has seen a sharp increase in the number of scientific publications
describing physiological and pathological functions of extracellular vesicles (EVs), a …

Extracellular vesicles in diagnostics and therapy of the ischaemic heart: Position Paper from the Working Group on Cellular Biology of the Heart of the European …

JPG Sluijter, SM Davidson, CM Boulanger… - Cardiovascular …, 2018 - academic.oup.com
Extracellular vesicles (EVs)—particularly exosomes and microvesicles (MVs)—are attracting
considerable interest in the cardiovascular field as the wide range of their functions is …

Extracellular vesicles: lipids as key components of their biogenesis and functions

M Record, S Silvente-Poirot, M Poirot… - Journal of lipid …, 2018 - ASBMB
Intercellular communication has been known for decades to involve either direct contact
between cells or to operate via circulating molecules, such as cytokines, growth factors, or …

Extracellular vesicles in human reproduction in health and disease

C Simon, DW Greening, D Bolumar… - Endocrine …, 2018 - academic.oup.com
Extensive evidence suggests that the release of membrane-enclosed compartments, more
commonly known as extracellular vesicles (EVs), is a potent newly identified mechanism of …

Comparison of membrane affinity-based method with size-exclusion chromatography for isolation of exosome-like vesicles from human plasma

R Stranska, L Gysbrechts, J Wouters… - Journal of translational …, 2018 - Springer
Abstract Background Plasma extracellular vesicles (EVs), especially exosome-like vesicles
(ELVs), are being increasingly explored as a source of potential noninvasive disease …

Methods and technologies for exosome isolation and characterization

M Zhang, K Jin, L Gao, Z Zhang, F Li, F Zhou… - Small …, 2018 - Wiley Online Library
Exosomes, a specific subclass of the extracellular vesicles secreted by most cell types, play
an important role in cell–cell communication by transporting diverse content including …

Plasma membrane lipid domains as platforms for vesicle biogenesis and shedding?

H Pollet, L Conrard, AS Cloos, D Tyteca - Biomolecules, 2018 - mdpi.com
Extracellular vesicles (EVs) contribute to several pathophysiological processes and appear
as emerging targets for disease diagnosis and therapy. However, successful translation from …

Cholesterol and the journey of extracellular vesicles

F Pfrieger, N Vitale - Journal of lipid research, 2018 - hal.science
Eukaryotic cells employ distinct means to release specific signals and material. Research
within the last decade has identified different types of membrane-enclosed structures …