The penetration of nanomedicine into solid tumor still constitutes a great challenge for
cancer therapy, which lead to the failure of thorough clearance of tumor cells. Aiming at …

Chemotherapy remains restricted by poor drug delivery efficacy due to the heterogenous
nature of tumor. Herein, we presented a novel nanoparticle that could not only response to …

Gold nanoparticles with unique optical and photo-thermal properties have promising
application in nanotheranostics, achieving the integration of diagnosis and therapy in a …

Background: The functional interplay between tumor cells and their adjacent stroma has
been suggested to play crucial roles in the initiation and progression of tumors and the …

Limited tumor targeting and poor penetration of nanoparticles are two major obstacles to
improving the outcome of tumor therapy. Herein, coadministration of tumor-homing peptide …

The complex tumor microenvironment (TME) in solid tumors forms physiological barriers to
the efficient delivery of nanomedicine, leading to limited therapeutic efficacy. Herein, to …

Densely extracellular matrix (ECM) is one of the main barriers that hinder the penetration of
drug into tumor parenchyma, compromising the therapeutic activity. In this work, alginic acid …

Physical oncology is an emerging paradigm which recognizes tissue mechanics, per se, as
an active modulator of tumorigenesis, treatment resistance and clinical outcome, mediated …

Self-assembly is a bottom-up strategy that can be used to construct a wide range of
nanostructures. This review discusses the applications of self-assembled nanomaterials in …

Background and purpose Nanoparticle-loaded hydrogels–localized drug delivery devices
containing a combination of therapeutic nanoparticles and implantable hydrogel–have been …