Executive summary The Sustainable Development Goals (SDGs) represent an exponential
advance from the Millennium Development Goals, with a substantially broader agenda …

Social relationships are adaptive and crucial for survival. This review presents existing
evidence indicating that our social connections to others have powerful influences on health …

Objective: Social support and social integration have been linked to lower rates of morbidity
and mortality. However, the biological mechanisms responsible for such links need greater …

Inflammation is the principal response invoked by the body to address injuries. Despite
inflammation constituting a crucial component of tissue repair, it is well known that …

Objective Numerous theories have proposed that acute and chronic stressors may exert a
cumulative effect on life-span health by causing biological “wear and tear,” or allostatic load …

Astrocyte dysfunction and inflammation are associated with the pathogenesis of major
depressive disorder (MDD). However, the mechanisms underlying these effects remain …

Previous research indicates there may be an association between inflammation and
depression in older adults but results are inconsistent. Therefore, the aim of this review was …

I have been given a priceless opportunity to reflect on my career in the remarkably
productive field of risk factors for depression. Psychological research on depression …

The understanding of mechanisms linking psychological stress to disease risk depend on
reliable stress biomarkers. Circulating cell-free DNA (cfDNA) has emerged as a potential …

Depression is a highly prevalent disorder, and its treatment is far from satisfactory. There is
an urgent need to develop a new treatment for depression. Although still at its early stage …