Over 350 million individuals suffer from depression, a psychiatric illness classified as major
depressive disorder (MDD) with symptoms that include a loss of interest or pleasure in life …

For decades, neurological, psychological, and cognitive alterations, as well as other
glandular manifestations (EGM), have been described and are being considered to be part …

In humans, depression is often associated with low-grade inflammation, activation of the
tryptophan/kynurenine pathway, and mild lymphopenia. Preclinical research confirms that …

Psychosocial stress is a major risk factor for depression, stress leads to peripheral and
central immune activation, immune activation is associated with blunted dopamine (DA) …

Patients suffering from chronic neuropathic pain are at high risk of co-morbid depression,
which burdens healthcare. Trans-astaxanthin has been shown in our previous studies to …

Background This study aims to explore the role of indoleamine-2, 3-dioxygenase
(IDO)/kynurenine (KYN) pathway of tryptophan (TRY) metabolism in behavioral alterations …

Both depression and cancer are related to a dysregulation of inflammatory and immune
pathways. Indeed, depression is associated with increased expression of interferon-γ …

Behavioral symptoms associated with mood disorders have been intimately linked with
immunological and psychological stress. Induction of immune and stress pathways is …

Background Peripheral immune challenge can elicit microglia activation and depression-
related symptoms. The balance of inflammatory signals in the tryptophan pathway can skew …

Depression is present in a large proportion of patients suffering from chronic pain, and yet
the underlying mechanisms remain to be elucidated. Neuroligins (NLs), as a family of cell …