Ecology and evolution of Mycobacterium tuberculosis
S Gagneux - Nature Reviews Microbiology, 2018 - nature.com
Tuberculosis (TB) is the number one cause of human death due to an infectious disease.
The causative agents of TB are a group of closely related bacteria known as the …
The causative agents of TB are a group of closely related bacteria known as the …
From theory to practice: translating whole-genome sequencing (WGS) into the clinic
Hospitals worldwide are facing an increasing incidence of hard-to-treat infections. Limiting
infections and providing patients with optimal drug regimens require timely strain …
infections and providing patients with optimal drug regimens require timely strain …
Genome-wide analysis of multi- and extensively drug-resistant Mycobacterium tuberculosis
To characterize the genetic determinants of resistance to antituberculosis drugs, we
performed a genome-wide association study (GWAS) of 6,465 Mycobacterium tuberculosis …
performed a genome-wide association study (GWAS) of 6,465 Mycobacterium tuberculosis …
MTBseq: a comprehensive pipeline for whole genome sequence analysis of Mycobacterium tuberculosis complex isolates
TA Kohl, C Utpatel, V Schleusener, MR De Filippo… - PeerJ, 2018 - peerj.com
Analyzing whole-genome sequencing data of Mycobacterium tuberculosis complex (MTBC)
isolates in a standardized workflow enables both comprehensive antibiotic resistance …
isolates in a standardized workflow enables both comprehensive antibiotic resistance …
Machine learning and structural analysis of Mycobacterium tuberculosis pan-genome identifies genetic signatures of antibiotic resistance
Mycobacterium tuberculosis is a serious human pathogen threat exhibiting complex
evolution of antimicrobial resistance (AMR). Accordingly, the many publicly available …
evolution of antimicrobial resistance (AMR). Accordingly, the many publicly available …
Frequent transmission of the Mycobacterium tuberculosis Beijing lineage and positive selection for the EsxW Beijing variant in Vietnam
To examine the transmission dynamics of Mycobacterium tuberculosis (Mtb) isolated from
tuberculosis patients in Ho Chi Minh City, Vietnam, we sequenced the whole genomes of …
tuberculosis patients in Ho Chi Minh City, Vietnam, we sequenced the whole genomes of …
Outbreak of multidrug-resistant tuberculosis in South Africa undetected by WHO-endorsed commercial tests: an observational study
NA Makhado, E Matabane, M Faccin… - The Lancet Infectious …, 2018 - thelancet.com
Background Global roll-out of rapid molecular assays is revolutionising the diagnosis of
rifampicin resistance, predictive of multidrug-resistance, in tuberculosis. However, 30% of …
rifampicin resistance, predictive of multidrug-resistance, in tuberculosis. However, 30% of …
Global expansion of Mycobacterium tuberculosis lineage 4 shaped by colonial migration and local adaptation
On the basis of population genomic and phylogeographic analyses of 1669 Mycobacterium
tuberculosis lineage 4 (L4) genomes, we find that dispersal of L4 has been completely …
tuberculosis lineage 4 (L4) genomes, we find that dispersal of L4 has been completely …
The relationship between transmission time and clustering methods in Mycobacterium tuberculosis epidemiology
Background Tracking recent transmission is a vital part of controlling widespread pathogens
such as Mycobacterium tuberculosis. Multiple methods with specific performance …
such as Mycobacterium tuberculosis. Multiple methods with specific performance …
China's tuberculosis epidemic stems from historical expansion of four strains of Mycobacterium tuberculosis
A small number of high-burden countries account for the majority of tuberculosis cases
worldwide. Detailed data are lacking from these regions. To explore the evolutionary history …
worldwide. Detailed data are lacking from these regions. To explore the evolutionary history …