For a long time, pioneers in the field of cancer cell metabolism, such as Otto Warburg, have
focused on the idea that tumor cells maintain high glycolytic rates even with adequate …

Endometrial cancer is the most common gynecologic malignancy in developed countries. Its
increasing incidence is thought to be related in part to the rise of metabolic syndrome, which …

Background: Metformin, an oral anti-hyperglycemic drug which inhibits mitochondrial
complex I and oxidative phosphorylation has been reported to correlate with improved …

The main objective of this study was to evaluate the effect of metformin, statins and anti-
inflammatory drugs (NSAIDs) on head and neck cancer (HNC). Specifically, the potential …

Background The antidiabetic drug metformin (Met) is believed to inhibit tumor proliferation
by altering the metabolism of cancer cells. In this study, we examined the effects of Met on …

Objective Many aggressive head and neck cancers contain 2 metabolically coupled tumor
compartments: a glycolytic stromal compartment with low caveolin-1 (CAV1) and high …

Assessing tumour response using a traditional phase I, II and III trial approach is not without
limitations, particularly when targeted therapies are involved. Window of opportunity trials …

For a long time, pioneers in the field of cancer cell metabolism, such as Otto Warburg, have
focused on the idea that tumor cells maintain high glycolytic rates even with adequate …

O carcinoma espinocelular (CEC) é a sexta malignidade mais comum do mundo, e na
região de cabeça e pescoço representa mais de 90% das malignidades. Mesmo com os …