DNA methylation is an essential epigenetic modification for mammalian embryonic
development and biology. The DNA methylation pattern across the genome, together with …

DNA methylation represents a fundamental epigenetic modification that regulates chromatin
architecture and gene transcription. Many diseases, including cancer, show aberrant …

Thymine DNA glycosylase (TDG) is a DNA repair enzyme that excises a variety of
mismatched or damaged nucleotides (nts), eg dU, dT, 5fC and 5caC. TDG is shown to play …

To decode the function and molecular recognition of several recently discovered cytosine
derivatives in the human genome–5‐hydroxymethylcytosine, 5‐formylcytosine, and 5 …

Recently described as the sixth base of the DNA macromolecule, the precise role of 5-
hydroxymethylcytosine (5hmC) is the subject of debate. Early studies indicate that it is …

Thymine DNA glycosylase (TDG) initiates base excision repair by cleaving the N-glycosidic
bond between the sugar and target base. After catalysis, the release of excised base is a …

In Caenorhabditis elegans, two DNA glycosylases, UNG-1 and NTH-1, and two AP
endonucleases, APN-1 and EXO-3, have been characterized from the base-excision repair …

Glycosylases specifically recognize and flip their target base out of the DNA helix into the
enzyme's active site. Our simulations show that a partially flipped state, already present in …

Alcohol use disorder (AUD) is a highly prevalent and pernicious substance use disorder that
is characterized by widespread changes to gene expression that may drive maladaptive …

This master's thesis is divided into a literature review and an experimental part. The
literature review starts with an introduction of nucleic acids and epigenetics, covering both …