Oxytocin is present in islets and plays a role in beta-cell function and survival
Oxytocin is associated mainly with modulating reproductive function. However, studies
suggest that oxytocin also plays a role in endocrine pancreatic function. In the present study …
suggest that oxytocin also plays a role in endocrine pancreatic function. In the present study …
Peptides from frog skin with potential for development into agents for Type 2 diabetes therapy
Several frog skin peptides, first identified as result of their antimicrobial or
immunomodulatory activities, have subsequently been shown to stimulate insulin release …
immunomodulatory activities, have subsequently been shown to stimulate insulin release …
Atlantic salmon (Salmo salar) co-product-derived protein hydrolysates: A source of antidiabetic peptides
PA Harnedy, V Parthsarathy, CM McLaughlin… - Food Research …, 2018 - Elsevier
Large quantities of low-value protein rich co-products, such as salmon skin and trimmings,
are generated annually. These co-products can be upgraded to high-value functional …
are generated annually. These co-products can be upgraded to high-value functional …
Blue whiting (Micromesistius poutassou) muscle protein hydrolysate with in vitro and in vivo antidiabetic properties
PA Harnedy, V Parthsarathy, CM McLaughlin… - Journal of Functional …, 2018 - Elsevier
A blue whiting (Micromesistius poutassou) protein hydrolysate generated using Alcalase 2.4
L and Flavourzyme 500L and its simulated gastrointestinal digestion (SGID) sample was …
L and Flavourzyme 500L and its simulated gastrointestinal digestion (SGID) sample was …
Novel dual incretin agonist peptide with antidiabetic and neuroprotective potential
Glucose-dependent insulinotropic hormone (GIP) and glucagon-like peptide-1 (GLP-1) are
incretin hormones that exert an array of beneficial actions on metabolism and cognitive …
incretin hormones that exert an array of beneficial actions on metabolism and cognitive …
Cellular models for beta‐cell function and diabetes gene therapy
AD Green, S Vasu, PR Flatt - Acta physiologica, 2018 - Wiley Online Library
Diabetes is characterized by the destruction and/or relative dysfunction of insulin‐secreting
beta‐cells in the pancreatic islets of Langerhans. Consequently, considerable effort has …
beta‐cells in the pancreatic islets of Langerhans. Consequently, considerable effort has …
Assessment of the potential of temporin peptides from the frog Rana temporaria (Ranidae) as anti‐diabetic agents
V Musale, B Casciaro, ML Mangoni… - Journal of Peptide …, 2018 - Wiley Online Library
Temporin A (FLPLIGRVLSGIL‐NH2), temporin F (FLPLIGKVLSGIL‐NH2), and temporin G
(FFPVIGRILNGIL‐NH2), first identified in skin secretions of the frog Rana temporaria …
(FFPVIGRILNGIL‐NH2), first identified in skin secretions of the frog Rana temporaria …
Apelin-13 analogues show potent in vitro and in vivo insulinotropic and glucose lowering actions
Nine structurally modified apelin-13 analogues were assessed for their in vitro and acute in
vivo antidiabetic potential. Stability was assessed in mouse plasma and insulinotropic …
vivo antidiabetic potential. Stability was assessed in mouse plasma and insulinotropic …
A novel GLP-1/xenin hybrid peptide improves glucose homeostasis, circulating lipids and restores GIP sensitivity in high fat fed mice
Combined modulation of peptide hormone receptors including, glucagon-like peptide-1
(GLP-1), glucose-dependent insulinotropic polypeptide (GIP) and xenin, have established …
(GLP-1), glucose-dependent insulinotropic polypeptide (GIP) and xenin, have established …
Expression of gastrin family peptides in pancreatic islets and their role in β-cell function and survival
Methods We assessed the impact of the CCK A and CCK B receptor modulators,(pGlu-Gln)-
CCK-8 and gastrin-17, respectively, on β-cell secretory function, proliferation and apoptosis …
CCK-8 and gastrin-17, respectively, on β-cell secretory function, proliferation and apoptosis …