Machine learning and structural analysis of Mycobacterium tuberculosis pan-genome identifies genetic signatures of antibiotic resistance
Mycobacterium tuberculosis is a serious human pathogen threat exhibiting complex
evolution of antimicrobial resistance (AMR). Accordingly, the many publicly available …
evolution of antimicrobial resistance (AMR). Accordingly, the many publicly available …
d-Cycloserine Pharmacokinetics/Pharmacodynamics, Susceptibility, and Dosing Implications in Multidrug-resistant Tuberculosis: A Faustian Deal
Background d-cycloserine is used to treat multidrug-resistant tuberculosis. Its efficacy,
contribution in combination therapy, and best clinical dose are unclear, also data on the d …
contribution in combination therapy, and best clinical dose are unclear, also data on the d …
Perspectives for personalized therapy for patients with multidrug‐resistant tuberculosis
Abstract According to the World Health Organization (WHO), tuberculosis is the leading
cause of death attributed to a single microbial pathogen worldwide. In addition to the large …
cause of death attributed to a single microbial pathogen worldwide. In addition to the large …
The role of the CroR response regulator in resistance of Enterococcus faecalis to D‐cycloserine is defined using an inducible receiver domain
C Muller, S Massier, Y Le Breton… - Molecular …, 2018 - Wiley Online Library
Enterococcus faecalis is an opportunistic multidrug‐resistant human pathogen causing
severe nosocomial infections. Previous investigations revealed that the CroRS two …
severe nosocomial infections. Previous investigations revealed that the CroRS two …
Antibiotic resistance evasion is explained by rare mutation frequency and not by lack of compensatory mechanisms
D Evangelopoulos, GA Prosser, A Rodgers, BM Dagg… - BioRxiv, 2018 - biorxiv.org
Drug resistant infections represent one of the most challenging medical problems of our
time. D-cycloserine is an antibiotic used for decades without appearance and dissemination …
time. D-cycloserine is an antibiotic used for decades without appearance and dissemination …
Structure, mechanism and engineering of pyridoxal phosphate-dependent racemases
A Frese - 2018 - etheses.whiterose.ac.uk
The objective of this work is the investigation and structural characterisation of pyridoxal
phosphate (PLP)-dependent racemases. In particular α-amino-ε-caprolactam racemases …
phosphate (PLP)-dependent racemases. In particular α-amino-ε-caprolactam racemases …
[引用][C] Technical report on critical concentrations for drug susceptibility testing of medicines used in the treatment of drug-resistant tuberculosis [WHO/CDS/TB/2018.5] …
S Georghiou - 2018