Recent progress in dendrimer-based nanomedicine development
Y Kim, EJ Park, DH Na - Archives of pharmacal research, 2018 - Springer
Dendrimers offer well-defined nanoarchitectures with spherical shape, high degree of
molecular uniformity, and multiple surface functionalities. Such unique structural properties …
molecular uniformity, and multiple surface functionalities. Such unique structural properties …
[HTML][HTML] Targeting mitochondrial dysfunction and oxidative stress in activated microglia using dendrimer-based therapeutics
Mitochondrial oxidative stress is associated with many neurodegenerative diseases, such as
traumatic brain injury (TBI). Targeted delivery of antioxidants to mitochondria has failed to …
traumatic brain injury (TBI). Targeted delivery of antioxidants to mitochondria has failed to …
Colloidal stability as a determinant of nanoparticle behavior in the brain
Drug delivery to the brain is challenging due to a highly regulated blood-brain barrier (BBB)
and a complex brain microenvironment. Nanoparticles, due to their tailorability, provide …
and a complex brain microenvironment. Nanoparticles, due to their tailorability, provide …
Harnessing nanostructured systems for improved treatment and prevention of HIV disease
M Monroe, C Flexner, H Cui - Bioengineering & translational …, 2018 - Wiley Online Library
Combination antiretroviral therapy effectively controls human immunodeficiency virus (HIV)
viral replication, delaying the progression to acquired immune deficiency syndrome and …
viral replication, delaying the progression to acquired immune deficiency syndrome and …
Scalable synthesis and validation of PAMAM dendrimer‐N‐acetyl cysteine conjugate for potential translation
Dendrimer‐N‐acetyl cysteine (D‐NAC) conjugate has shown significant promise in multiple
preclinical models of brain injury and is undergoing clinical translation. D‐NAC is a …
preclinical models of brain injury and is undergoing clinical translation. D‐NAC is a …
Brain delivery of multifunctional dendrimer protein bioconjugates
Neurological disorders are undoubtedly among the most alarming diseases humans might
face. In treatment of neurological disorders, the blood‐brain barrier (BBB) is a challenging …
face. In treatment of neurological disorders, the blood‐brain barrier (BBB) is a challenging …
Dendrimer–N‐acetyl‐L‐cysteine modulates monophagocytic response in adrenoleukodystrophy
Objective X‐linked adrenoleukodystrophy (ALD) is a neurodegenerative disorder due to
mutations in the peroxisomal very long‐chain fatty acyl‐CoA transporter, ABCD1, with …
mutations in the peroxisomal very long‐chain fatty acyl‐CoA transporter, ABCD1, with …
Pediatric oral formulation of dendrimer-N-acetyl-l-cysteine conjugates for the treatment of neuroinflammation
VK Yellepeddi, R Mohammadpour… - International journal of …, 2018 - Elsevier
Abstract N-Acetyl-l-cysteine (NAC) commonly used as an antidote in acetaminophen
poisoning has shown promise in the treatment of neurological disorders such as cerebral …
poisoning has shown promise in the treatment of neurological disorders such as cerebral …
Quantitative assessment of surface functionality effects on microglial uptake and retention of PAMAM dendrimers
Dendrimers are a promising class of polymeric nanoparticles for delivery of therapeutics and
diagnostics. Polyamidoamine (PAMAM) dendrimers have shown significant efficacy in many …
diagnostics. Polyamidoamine (PAMAM) dendrimers have shown significant efficacy in many …
[HTML][HTML] Modeling inflammation in autism spectrum disorders using stem cells
BC Freitas, A Mei, APD Mendes… - Frontiers in …, 2018 - frontiersin.org
Recent reports show an increase in the incidence of Autism Spectrum Disorders (ASD) to 1
in every 59 children up to 8 years old in 11 states in North America. Induced pluripotent stem …
in every 59 children up to 8 years old in 11 states in North America. Induced pluripotent stem …