Antifungals discovery: an insight into new strategies to combat antifungal resistance
AM Fuentefria, B Pippi, DF Dalla Lana… - Letters in applied …, 2018 - academic.oup.com
Undeniably, new antifungal treatments are necessary against pathogenic fungi. Fungal
infections have significantly increased in recent decades, being highlighted as important …
infections have significantly increased in recent decades, being highlighted as important …
Synthesis, characterization, DNA binding and antitumor activities of Cu (II) complexes
A series of Cu (II) complexes of 5, 5-dimethyl-2-(2-arylhydrazono) cyclohexane-1, 3-dione
(HL n) were synthesized by the coupling of dimedone with aniline and its derivatives. These …
(HL n) were synthesized by the coupling of dimedone with aniline and its derivatives. These …
The synthesis, antifungal and apoptotic effects of triazole-oxadiazoles against Candida species
In search of potent and safe antifungal agents, herein, we report the synthesis,
characterization and biological activities of triazole-oxadiazole compounds. The structural …
characterization and biological activities of triazole-oxadiazole compounds. The structural …
[HTML][HTML] Synthesis and evaluation of new 1, 3, 4-thiadiazole derivatives as potent antifungal agents
With the goal of obtaining a novel bioactive compound with significant antifungal activity, a
series of 1, 3, 4-thiadiazole derivatives (3a–3l) were synthesized and characterized. Due to …
series of 1, 3, 4-thiadiazole derivatives (3a–3l) were synthesized and characterized. Due to …
[HTML][HTML] Synthesis and anticandidal activity of new imidazole-chalcones
In the present work, 15 new 1-(4-(1 H-imidazol-1-yl) phenyl)-3-(4-substituedphenyl) prop-2-
en-1-one derivatives (3a–3o) were synthesized to evaluate their antifungal activity …
en-1-one derivatives (3a–3o) were synthesized to evaluate their antifungal activity …
[HTML][HTML] Design, Synthesis and Biological Evaluation of Novel N-Pyridyl-Hydrazone Derivatives as Potential Monoamine Oxidase (MAO) Inhibitors
A new series of N-pyridyl-hydrazone derivatives was synthesized by using a simple and
efficient method. The final compounds obtained were screened for their inhibitory potency …
efficient method. The final compounds obtained were screened for their inhibitory potency …
Triazoles: Multidimensional 5-membered nucleus for designing multitargeting agents
A Kashyap, O Silakari - Key Heterocycle Cores for Designing Multitargeting …, 2018 - Elsevier
The traditional approach of the drug discovery process involves the designing of ligands
with maximum selectivity for a particular target leading to a prolonged effect. Therefore, a …
with maximum selectivity for a particular target leading to a prolonged effect. Therefore, a …
Design and evaluation of biological activities of 1, 3‐oxazolidinone derivatives bearing amide, sulfonamide, and thiourea moieties
Oxazolidine‐2‐one is an important heterocyclic ring participating in the chemical structure of
many drugs. In this research, 22 new amide/sulfonamide/thiourea derivatives (1–22) were …
many drugs. In this research, 22 new amide/sulfonamide/thiourea derivatives (1–22) were …
Synthesis and antimicrobial activity of new 2-((1-furan-2-yl) ethylidene) hydrazono)-4-phenylthiazol-3 (2H)-amine derivatives and their schiff bases with 4 …
Abstract A new series of 2-((1-furan-2-yl) ethylidene) hydrazono)-4-substitutedphenylthiazol-
3 (2 H)-amines (2a–2o) and their Schiff bases (3a–3o) from 4-nitrobenzaldehyde were …
3 (2 H)-amines (2a–2o) and their Schiff bases (3a–3o) from 4-nitrobenzaldehyde were …