Antifungals discovery: an insight into new strategies to combat antifungal resistance

AM Fuentefria, B Pippi, DF Dalla Lana… - Letters in applied …, 2018 - academic.oup.com
Undeniably, new antifungal treatments are necessary against pathogenic fungi. Fungal
infections have significantly increased in recent decades, being highlighted as important …

Synthesis, characterization, DNA binding and antitumor activities of Cu (II) complexes

AF Shoair, AA El-Bindary, NA El-Ghamaz… - Journal of Molecular …, 2018 - Elsevier
A series of Cu (II) complexes of 5, 5-dimethyl-2-(2-arylhydrazono) cyclohexane-1, 3-dione
(HL n) were synthesized by the coupling of dimedone with aniline and its derivatives. These …

The synthesis, antifungal and apoptotic effects of triazole-oxadiazoles against Candida species

BK Çavuşoğlu, L Yurttaş, Z Cantürk - European journal of medicinal …, 2018 - Elsevier
In search of potent and safe antifungal agents, herein, we report the synthesis,
characterization and biological activities of triazole-oxadiazole compounds. The structural …

[HTML][HTML] Synthesis and evaluation of new 1, 3, 4-thiadiazole derivatives as potent antifungal agents

AÇ Karaburun, U Acar Çevik, D Osmaniye, BN Sağlık… - Molecules, 2018 - mdpi.com
With the goal of obtaining a novel bioactive compound with significant antifungal activity, a
series of 1, 3, 4-thiadiazole derivatives (3a–3l) were synthesized and characterized. Due to …

[HTML][HTML] Synthesis and anticandidal activity of new imidazole-chalcones

D Osmaniye, B Kaya Cavusoglu, BN Saglik, S Levent… - Molecules, 2018 - mdpi.com
In the present work, 15 new 1-(4-(1 H-imidazol-1-yl) phenyl)-3-(4-substituedphenyl) prop-2-
en-1-one derivatives (3a–3o) were synthesized to evaluate their antifungal activity …

[HTML][HTML] Design, Synthesis and Biological Evaluation of Novel N-Pyridyl-Hydrazone Derivatives as Potential Monoamine Oxidase (MAO) Inhibitors

G Turan-Zitouni, W Hussein, BN Sağlık, A Tabbi… - Molecules, 2018 - mdpi.com
A new series of N-pyridyl-hydrazone derivatives was synthesized by using a simple and
efficient method. The final compounds obtained were screened for their inhibitory potency …

Triazoles: Multidimensional 5-membered nucleus for designing multitargeting agents

A Kashyap, O Silakari - Key Heterocycle Cores for Designing Multitargeting …, 2018 - Elsevier
The traditional approach of the drug discovery process involves the designing of ligands
with maximum selectivity for a particular target leading to a prolonged effect. Therefore, a …

Design and evaluation of biological activities of 1, 3‐oxazolidinone derivatives bearing amide, sulfonamide, and thiourea moieties

N Karaman, R Adil Zainel, HA Kapkaç… - Archiv der …, 2018 - Wiley Online Library
Oxazolidine‐2‐one is an important heterocyclic ring participating in the chemical structure of
many drugs. In this research, 22 new amide/sulfonamide/thiourea derivatives (1–22) were …

Synthesis and antimicrobial activity of new 2-((1-furan-2-yl) ethylidene) hydrazono)-4-phenylthiazol-3 (2H)-amine derivatives and their schiff bases with 4 …

G Turan-Zitoun, BN Sağlik, UA Çevik… - … , Sulfur, and Silicon …, 2018 - Taylor & Francis
Abstract A new series of 2-((1-furan-2-yl) ethylidene) hydrazono)-4-substitutedphenylthiazol-
3 (2 H)-amines (2a–2o) and their Schiff bases (3a–3o) from 4-nitrobenzaldehyde were …

[引用][C] Design, Synthesis and Biological Evaluation of Novel N-Pyridyl-Hydrazone Derivatives as Potential Monoamine Oxidase (MAO) Inhibitors

G Turan, W Hussein, BN Sağlık, A Tabbi, B Korkut - 2018 - MDPI