Smart biomaterials have the ability to respond to changes in physiological parameters and
exogenous stimuli and continue to impact many aspects of modern medicine. Smart …

The cell microenvironment choreographs the behaviors of cells through multiple well-
controlled signals. For basic biological study and cell-based therapies, it is essential to …

Modern optical detection technology plays a critical role in current clinical detection due to
its high sensitivity and accuracy. However, higher requirements such as extremely high …

Circulating tumor cell (CTC) enumeration and analysis has emerged as an important
platform for cancer diagnosis and prognosis. A great challenge, however, is to efficiently …

Cancer is the second leading cause of death worldwide. Researchers have been working
hard on investigating not only improved therapeutics but also on early detection methods …

As a conventional amplification technique, polymerase chain reaction (PCR) has been
widely applied to detect a variety of analytes with exponential amplification efficiency …

Enhancing the limit of detection (LOD) is significant for crucial diseases. Cancer
development could take more than 10 years, from one mutant cell to a visible tumor. Early …

Circulating tumor cells (CTCs) are cancer cells shredded from either a primary tumor or a
metastatic site and circulate in the blood as the potential cellular origin of metastasis. By …

Cell-to-cell variation in gene expression creates a need for techniques that can characterize
expression at the level of individual cells. This is particularly true for rare circulating tumour …

Isolation of circulating tumor cells (CTCs) from blood has long been a challenge due to the
rarity and heterogeneity of these cells. Detection technologies have predominantly focused …