Progranulin (PGRN), encoded by the GRN gene in humans, is a secreted growth factor
implicated in a multitude of processes ranging from regulation of inflammation to wound …

Alzheimer's disease (AD) represents an impending global health crisis, yet the complexity of
AD pathophysiology has so far precluded the development of any interventions to …

Identifying genetic variants associated with circulating protein concentrations (protein
quantitative trait loci; pQTLs) and integrating them with variants from genome-wide …

Inflammation and apoptosis play important roles in the initiation and progression of acute
lung injury (ALI). Our previous study has shown that progranulin (PGRN) exerts lung …

Loss-of-function mutations in progranulin, a lysosomal glycoprotein, cause
neurodegenerative disease. Progranulin haploinsufficiency causes frontotemporal dementia …

Progranulin (PGRN) is predominantly expressed by microglia in the brain, and genetic and
experimental evidence suggests a critical role in Alzheimer's disease (AD). We asked …

Background Heterozygous loss-of-function mutations in the progranulin gene (GRN) lead to
frontotemporal lobar degeneration (FTLD) while the complete loss of progranulin (PGRN) …

The amyloid precursor protein (APP), one key player in Alzheimer's disease (AD), is
extensively processed by different proteases. This leads to the generation of diverging …

Frontotemporal dementia (FTD) is a neurodegenerative disorder characterized by
progressive changes in behavior, personality, and language with involvement of the frontal …

The purpose of this brief overview of the progranulin protein is to provide a sense of the
range and extent of the roles of progranulin in normal physiology and pathology …