This paper reviews the research evidence concerning the intergenerational transmission of
trauma effects and the possible role of epigenetic mechanisms in this transmission. Two …

The neurobiological understanding of mood, and by extension mood disorders, remains
elusive despite decades of research implicating several neuromodulator systems. This …

Mindfulness-Based interventions have increased in popularity in psychiatry, but the impact
of these treatments on disorder-relevant biomarkers would greatly enhance efficacy and …

The pathogenesis of anxiety disorders is multifactorial, involving complex interactions
between biological factors, environmental influences and psychological mechanisms …

Abstract Adverse Childhood Experiences (ACEs) are stressful and/or traumatic experiences
that occur during childhood. Research has demonstrated a link between ACEs and risk of …

Given the high prevalence of early life stress (ELS) and the potential physiological
dysregulation such experiences can lead to, this meta-analysis tested the relationship …

Socially disadvantaged individuals are at greater risk for simultaneously being exposed to
adverse social and environmental conditions. Although the mechanisms underlying joint …

Background: Child maltreatment is a major public problem, associated with enormous
consequences on the individual and socioeconomic level. Studies show a clear impact of …

Many promising findings support the notion that social relationships can dampen
hypothalamic-pituitary-adrenocortical (HPA) axis stress responses and protect individuals …

Objectives Suicide is a global health issue. Dysregulated hypothalamic-pituitary-adrenal
(HPA) axis activity, as measured by cortisol levels, has been identified as one potential risk …