Epigenetic regulation of cancer progression by EZH2: from biological insights to therapeutic potential
L Gan, Y Yang, Q Li, Y Feng, T Liu, W Guo - Biomarker research, 2018 - Springer
Enhancer of zeste homolog 2 (EZH2), a histone methyltransferase and a catalytic
component of PRC2, catalyzes tri-methylation of histone H3 at Lys 27 (H3K27me3) to …
component of PRC2, catalyzes tri-methylation of histone H3 at Lys 27 (H3K27me3) to …
Biochemical and epigenetic insights into L-2-hydroxyglutarate, a potential therapeutic target in renal cancer
Abstract Purpose: Elevation of L-2-hydroxylgutarate (L-2-HG) in renal cell carcinoma (RCC)
is due in part to reduced expression of L-2-HG dehydrogenase (L2HGDH). However, the …
is due in part to reduced expression of L-2-HG dehydrogenase (L2HGDH). However, the …
Therapeutic targeting of sunitinib-induced AR phosphorylation in renal cell carcinoma
R Adelaiye-Ogala, NP Damayanti, AR Orillion, S Arisa… - Cancer research, 2018 - AACR
Androgen receptor (AR) plays a crucial role in the development and progression of prostate
cancer. AR expression has also been reported in other solid tumors, including renal cell …
cancer. AR expression has also been reported in other solid tumors, including renal cell …