Neuroscience of addiction: relevance to prevention and treatment
ND Volkow, M Boyle - American Journal of Psychiatry, 2018 - Am Psychiatric Assoc
Addiction, the most severe form of substance use disorder, is a chronic brain disorder
molded by strong biosocial factors that has devastating consequences to individuals and to …
molded by strong biosocial factors that has devastating consequences to individuals and to …
Catalytic reaction mechanism for drug metabolism in human carboxylesterase-1: cocaine hydrolysis pathway
Carboxylesterase-1 (CE-1) is a crucial enzyme responsible for metabolism/activation/
inactivation of xenobiotics (therapeutic agents, prodrugs, abused drugs, and …
inactivation of xenobiotics (therapeutic agents, prodrugs, abused drugs, and …
Kinetic characterization of cholinesterases and a therapeutically valuable cocaine hydrolase for their catalytic activities against heroin and its metabolite 6 …
As the most popularly abused one of opioids, heroin is actually a prodrug. In the body,
heroin is hydrolyzed/activated to 6-monoacetylmorphine (6-MAM) first and then to morphine …
heroin is hydrolyzed/activated to 6-monoacetylmorphine (6-MAM) first and then to morphine …
Development and Preclinical Evaluation of Long-lasting Cocaine Hydrolases for Cocaine Overdose and Cocaine Use Disorder Treatment
T Zhang - 2018 - uknowledge.uky.edu
Cocaine is a plant-based illicit drug commonly involved in substance use disorder. Although
cocaine overdose and cocaine use disorders cause adverse health consequences to …
cocaine overdose and cocaine use disorders cause adverse health consequences to …
Characterization and Engineering of Human Proteins as Therapeutic Candidates
K Kim - 2018 - uknowledge.uky.edu
Protein engineering has been a useful tool in the fight against human diseases. Human
insulin was the first recombinant DNA-derived therapeutic protein (Humulin®) approved by …
insulin was the first recombinant DNA-derived therapeutic protein (Humulin®) approved by …