Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals
Here we conducted a large-scale genetic association analysis of educational attainment in a
sample of approximately 1.1 million individuals and identify 1,271 independent genome …
sample of approximately 1.1 million individuals and identify 1,271 independent genome …
Using an atlas of gene regulation across 44 human tissues to inform complex disease-and trait-associated variation
We apply integrative approaches to expression quantitative loci (eQTLs) from 44 tissues
from the Genotype-Tissue Expression project and genome-wide association study data …
from the Genotype-Tissue Expression project and genome-wide association study data …
Genetic identification of brain cell types underlying schizophrenia
With few exceptions, the marked advances in knowledge about the genetic basis of
schizophrenia have not converged on findings that can be confidently used for precise …
schizophrenia have not converged on findings that can be confidently used for precise …
Identifying gene targets for brain-related traits using transcriptomic and methylomic data from blood
Understanding the difference in genetic regulation of gene expression between brain and
blood is important for discovering genes for brain-related traits and disorders. Here, we …
blood is important for discovering genes for brain-related traits and disorders. Here, we …
Genome-wide mega-analysis identifies 16 loci and highlights diverse biological mechanisms in the common epilepsies
Nature communications, 2018 - nature.com
The epilepsies affect around 65 million people worldwide and have a substantial missing
heritability component. We report a genome-wide mega-analysis involving 15,212 …
heritability component. We report a genome-wide mega-analysis involving 15,212 …
Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression
Major depressive disorder (MDD) is a common illness accompanied by considerable
morbidity, mortality, costs, and heightened risk of suicide. We conducted a genome-wide …
morbidity, mortality, costs, and heightened risk of suicide. We conducted a genome-wide …
Elucidating the genetic basis of social interaction and isolation
The negative impacts of social isolation and loneliness on health are well documented.
However, little is known about their possible biological determinants. In up to 452,302 UK …
However, little is known about their possible biological determinants. In up to 452,302 UK …
Tracing early neurodevelopment in schizophrenia with induced pluripotent stem cells
Schizophrenia (SCZ) is a devastating mental disorder that is characterized by distortions in
thinking, perception, emotion, language, sense of self, and behavior. Epidemiological …
thinking, perception, emotion, language, sense of self, and behavior. Epidemiological …
Functional architecture of low-frequency variants highlights strength of negative selection across coding and non-coding annotations
Common variant heritability has been widely reported to be concentrated in variants within
cell-type-specific non-coding functional annotations, but little is known about low-frequency …
cell-type-specific non-coding functional annotations, but little is known about low-frequency …
Leveraging molecular quantitative trait loci to understand the genetic architecture of diseases and complex traits
There is increasing evidence that many risk loci found using genome-wide association
studies are molecular quantitative trait loci (QTLs). Here we introduce a new set of functional …
studies are molecular quantitative trait loci (QTLs). Here we introduce a new set of functional …