Ubiquitin ligases in oncogenic transformation and cancer therapy
The cellular response to external stress signals and DNA damage depends on the activity of
ubiquitin ligases (E3s), which regulate numerous cellular processes, including homeostasis …
ubiquitin ligases (E3s), which regulate numerous cellular processes, including homeostasis …
SETDB1 links the meiotic DNA damage response to sex chromosome silencing in mice
T Hirota, P Blakeley, MN Sangrithi, SK Mahadevaiah… - Developmental cell, 2018 - cell.com
Meiotic synapsis and recombination ensure correct homologous segregation and genetic
diversity. Asynapsed homologs are transcriptionally inactivated by meiotic silencing, which …
diversity. Asynapsed homologs are transcriptionally inactivated by meiotic silencing, which …
BRCA1-dependent transcriptional regulation: implication in tissue-specific tumor suppression
X Zhang, R Li - Cancers, 2018 - mdpi.com
Germ-line mutations in breast cancer susceptibility gene 1 (BRCA1) predominantly
predispose women to breast and ovarian cancers. BRCA1 is best known for its functions in …
predispose women to breast and ovarian cancers. BRCA1 is best known for its functions in …
Gene prioritization, communality analysis, networking and metabolic integrated pathway to better understand breast cancer pathogenesis
Consensus strategy was proved to be highly efficient in the recognition of gene-disease
association. Therefore, the main objective of this study was to apply theoretical approaches …
association. Therefore, the main objective of this study was to apply theoretical approaches …
[HTML][HTML] MiR-29b-1-5p is altered in BRCA1 mutant tumours and is a biomarker in basal-like breast cancer
MJG Milevskiy, GK Sandhu, A Wronski, D Korbie… - Oncotarget, 2018 - ncbi.nlm.nih.gov
Depletion of BRCA1 protein in mouse mammary glands results in defects in lactational
development and increased susceptibility to mammary cancer. Extensive work has focussed …
development and increased susceptibility to mammary cancer. Extensive work has focussed …
Matricellular CCN6 (WISP3) protein: a tumor suppressor for mammary metaplastic carcinomas
MN Tran, CG Kleer - Journal of cell communication and signaling, 2018 - Springer
Abstract Located at 6q22–23, Ccn6 (WISP3) encodes for a matrix-associated protein of the
CCN family, characterized by regulatory, rather than structural, roles in development and …
CCN family, characterized by regulatory, rather than structural, roles in development and …
[HTML][HTML] BRCA1 and BRCA2 tumor suppressors in neural crest cells are essential for craniofacial bone development
Craniofacial abnormalities, including facial skeletal defects, comprise approximately one-
third of all birth defects in humans. Since most bones in the face derive from cranial neural …
third of all birth defects in humans. Since most bones in the face derive from cranial neural …
[HTML][HTML] Induced Cre-mediated knockdown of Brca1 in skeletal muscle reduces mitochondrial respiration and prevents glucose intolerance in adult mice on a high-fat …
KC Jackson, MD Tarpey, AP Valencia, MR Iñigo… - The FASEB …, 2018 - ncbi.nlm.nih.gov
The breast cancer type 1 susceptibility protein (Brca1) is a regulator of DNA repair in
mammary gland cells; however, recent cell culture evidence suggests that Brca1 influences …
mammary gland cells; however, recent cell culture evidence suggests that Brca1 influences …
NF-κB at the Crossroads of Normal Mammary Gland Biology and the Pathogenesis and Prevention of BRCA1-Mutated Breast Cancer
A Sau, MA Cabrita, MAC Pratt - Cancer Prevention Research, 2018 - AACR
Recent studies have shown that progesterone receptor (PR)–expressing cells respond to
progesterone in part through the induction of the receptor activator of NF-κB ligand (RANKL) …
progesterone in part through the induction of the receptor activator of NF-κB ligand (RANKL) …
Evidence of Intertissue Differences in the DNA Damage Response and the Pro-oncogenic Role of NF-κB in Mice with Disengaged BRCA1–PALB2 Interaction
Abstract The BRCA1–PALB2–BRCA2 axis plays an essential role in DNA homologous
recombination repair, defect in which drives genome instability and cancer development …
recombination repair, defect in which drives genome instability and cancer development …