Runx2 is a transcription factor that is essential for osteoblast differentiation and chondrocyte
maturation. Ihh, expressed in prehypertrophic and hypertrophic chondrocytes, is required for …

Mesenchymal stem cells (MSCs) can differentiate into several lineages during development
and also contribute to tissue homeostasis and regeneration, although the requirements for …

Bone homeostasis is a complex process, wherein osteoclasts resorb bone and osteoblasts
produce new bone tissue. For the maintenance of skeletal integrity, this sequence has to be …

Hippo signaling plays critical roles in regulation of tissue homeostasis, organ size, and
tumorigenesis by inhibiting YES-associated protein (YAP) and PDZ-binding protein TAZ …

The functions of the paralogous transcriptional coactivators Yes-associated protein (YAP)
and transcriptional coactivator with PDZ-binding motif (TAZ) in bone are controversial. Each …

Pancreatic cancer remains one of the most lethal forms of cancer with a 10-year survival of<
1%. With little improvement in survival rates observed in the past 40 years, there is a …

The related transcriptional co-factors YAP (Yes-associated protein) and TAZ (transcriptional
co-activator with PDZ-binding motif) have been proposed to either promote or inhibit …

In the neural primordium of vertebrate embryos, the neural crest (NC) displays a unique
character: the capacity of its component cells to leave the neural primordium, migrate along …

Exercise is an evolutionary conserved survival function that nowadays has beneficial health
effects. The increased metabolic activity of contracting skeletal muscle affects the biology of …

The study of murine dendritic cell (DC) development has been integral to the identification of
specialized DC subsets that have unique requirements for their form and function. Advances …